The polyketides dihydroplakortin (3), and the dodecanoic acid derivatives 4 and 5. were isolated from the Caribbean marine sponge Plakortis simplex, and their structures fully characterized by spectroscopic and chemical means. The absolute stereochemistries of the known plakortin (1) and of compounds 3-5 were determined by applying Mosher's and Kusumi's methods on opportune degradation products. The isolated compounds exhibilexl cytotoxic activity tested in vitro on WEH1 164, marine fibrosarcoma cell line
Metabolites From The Sponge Plakortis simplex. Determination of Absolute Stereochemistry of Plakortin. Isolation and Stereostructure of Three Plakortin Related Compounds / F., Cafieri; Fattorusso, Ernesto; TAGLIALATELA SCAFATI, Orazio; Ianaro, Angela. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 55:(1999), pp. 7045-7056. [10.1016/S0040-4020(99)00332-4]
Metabolites From The Sponge Plakortis simplex. Determination of Absolute Stereochemistry of Plakortin. Isolation and Stereostructure of Three Plakortin Related Compounds.
FATTORUSSO, ERNESTO;TAGLIALATELA SCAFATI, ORAZIO;IANARO, ANGELA
1999
Abstract
The polyketides dihydroplakortin (3), and the dodecanoic acid derivatives 4 and 5. were isolated from the Caribbean marine sponge Plakortis simplex, and their structures fully characterized by spectroscopic and chemical means. The absolute stereochemistries of the known plakortin (1) and of compounds 3-5 were determined by applying Mosher's and Kusumi's methods on opportune degradation products. The isolated compounds exhibilexl cytotoxic activity tested in vitro on WEH1 164, marine fibrosarcoma cell lineI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
