Feroxosides A and B, have been isolated from the polar extract of the Caribbean sponge Ectyoplasia ferox. Their structures have been determined to be unusual C-4 nor-lanostane triterpenes glycosylated with a rhamnose containing tetrasaccharide chain, by interpretation of spectral data and chemical degradation. Absolute stereochemistry at C-23 has been determined by application of the modified Mosher method for secondary alcohols. Feroxosides A-B are moderately cytotoxic (IC50 19 microg/mL) against murine monocyte-macrophage cell line.
Feroxosides A-B, Two Norlanostane Tetraglycosides from the Caribbean Sponge Ectyoplasia ferox / C., Campagnuolo; Fattorusso, Ernesto; TAGLIALATELA SCAFATI, Orazio. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 56:(2001), pp. 4049-4055. [10.1016/S0040-4020(01)00287-3]
Feroxosides A-B, Two Norlanostane Tetraglycosides from the Caribbean Sponge Ectyoplasia ferox.
FATTORUSSO, ERNESTO;TAGLIALATELA SCAFATI, ORAZIO
2001
Abstract
Feroxosides A and B, have been isolated from the polar extract of the Caribbean sponge Ectyoplasia ferox. Their structures have been determined to be unusual C-4 nor-lanostane triterpenes glycosylated with a rhamnose containing tetrasaccharide chain, by interpretation of spectral data and chemical degradation. Absolute stereochemistry at C-23 has been determined by application of the modified Mosher method for secondary alcohols. Feroxosides A-B are moderately cytotoxic (IC50 19 microg/mL) against murine monocyte-macrophage cell line.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
