Two new steroidal derivatives, named clionastatins A and B, have been isolated from the burrowing sponge Cliona nigricans. These molecules are tri-and tetra-chlorinated androstane derivatives, respectively, and they represent the first polyhalogenated steroids found in a natural organism, either marine or terrestrial, and the first examples of halogenated androstanes in nature. Both clionastatins proved to be potently cytotoxic.
Polychlorinated Androstanes From the Burrowing Sponge Cliona nigricans / E. FATTORUSSO, E.; Petrucci, F.; TAGLIALATELA SCAFATI, Orazio; Bavestrello, G.; Calcinai, B.; Cerrano, C.; DI MEGLIO, P.; Ianaro, Angela. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 6:(2004), pp. 1633-1635. [10.1021/ol049548r]
Polychlorinated Androstanes From the Burrowing Sponge Cliona nigricans
TAGLIALATELA SCAFATI, ORAZIO;IANARO, ANGELA
2004
Abstract
Two new steroidal derivatives, named clionastatins A and B, have been isolated from the burrowing sponge Cliona nigricans. These molecules are tri-and tetra-chlorinated androstane derivatives, respectively, and they represent the first polyhalogenated steroids found in a natural organism, either marine or terrestrial, and the first examples of halogenated androstanes in nature. Both clionastatins proved to be potently cytotoxic.| File | Dimensione | Formato | |
|---|---|---|---|
|
ArticlePDF.pdf
non disponibili
Tipologia:
Documento in Post-print
Licenza:
Accesso privato/ristretto
Dimensione
52.77 kB
Formato
Adobe PDF
|
52.77 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
