HPLC and ESI-MS analysis have been used to investigate the effect of acrolein exposure on d(TTAGGG)(4) human telomeric repeat. Preliminary results disclosed a novel relationship between the structure assumed by oligodeoxynucleotides (ODNs) and the capability of their nucleobase residues to react with acrolein.
Effects of acrolein on the quadruplex forming d(TTAGGG)4 telomeric repeat sequence / Borbone, Nicola; D'Isa, Giuliana; Oliviero, Giorgia; Piccialli, Gennaro; Varra, Michela; Mayol, Luciano. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 24:(2005), pp. 447-450. [10.1081/NCN-200059993]
Effects of acrolein on the quadruplex forming d(TTAGGG)4 telomeric repeat sequence.
BORBONE, NICOLA;D'ISA, GIULIANA;OLIVIERO, GIORGIA;PICCIALLI, GENNARO;VARRA, MICHELA;MAYOL, LUCIANO
2005
Abstract
HPLC and ESI-MS analysis have been used to investigate the effect of acrolein exposure on d(TTAGGG)(4) human telomeric repeat. Preliminary results disclosed a novel relationship between the structure assumed by oligodeoxynucleotides (ODNs) and the capability of their nucleobase residues to react with acrolein.File in questo prodotto:
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