Oligonucleotides with a 3-3 inversion of polarity, containing an acridine moiety attached to the nucleotide base flanking the 3-3 phosphodiester bond, have been synthesised, characterised and used to form alternate-strand triple helix complexes. These have been investigated by UV melting studies and CD experiments.
Synthesis of 3'-3'-linked pyrimidine oligonucleotides containing an acridine moiety for alternate strand triple helix formation / Amato, Jussara; Galeone, Aldo; Oliviero, Giorgia; Mayol, Luciano; Piccialli, Gennaro; Varra, Michela. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - 11(2004), pp. 2331-2336. [10.1002/ejoc.200300803]
Synthesis of 3'-3'-linked pyrimidine oligonucleotides containing an acridine moiety for alternate strand triple helix formation
AMATO, JUSSARA;GALEONE, ALDO;OLIVIERO, GIORGIA;MAYOL, LUCIANO;PICCIALLI, GENNARO;VARRA, MICHELA
2004
Abstract
Oligonucleotides with a 3-3 inversion of polarity, containing an acridine moiety attached to the nucleotide base flanking the 3-3 phosphodiester bond, have been synthesised, characterised and used to form alternate-strand triple helix complexes. These have been investigated by UV melting studies and CD experiments.| File | Dimensione | Formato | |
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