Multiple sclerosis (MS) is a complex disease that seems to depend on several pathophysiological processes. In this paper, we demonstrate that an aberrant N-glucosylation is a fundamental determinant of autoAb recognition in MS. Thus, we developed CSF114(Glc), an antigenic probe accurately measuring IgM autoAbs in the sera of a patient population, as disease biomarker. A CSF114(Glc)-based immunoassay on sera may have important prognostic value in monitoring MS disease progression guiding optimal therapeutic treatment.
An N-Glucosylated Peptide Detecting Disease-Specific Autoantibodies, Biomarkers of Multiple Sclerosis / Lolli, F; Mulinacci, B; Carotenuto, Alfonso; Bonetti, B; Sabatino, G; Mazzanti, B; D'Ursi, A. M.; Novellino, E; Pazzagli, M; Lovato, L; Alcaro, M. C.; Peroni, E; POZO CARRERO, M. C.; Nuti, F; Battistini, L; Borsellino, G; Chelli, M; Rovero, P; Papini, A. M.. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - STAMPA. - 102:29(2005), pp. 10273-10278. [10.1073/pnas.0503178102]
An N-Glucosylated Peptide Detecting Disease-Specific Autoantibodies, Biomarkers of Multiple Sclerosis
CAROTENUTO, ALFONSO;NOVELLINO E;
2005
Abstract
Multiple sclerosis (MS) is a complex disease that seems to depend on several pathophysiological processes. In this paper, we demonstrate that an aberrant N-glucosylation is a fundamental determinant of autoAb recognition in MS. Thus, we developed CSF114(Glc), an antigenic probe accurately measuring IgM autoAbs in the sera of a patient population, as disease biomarker. A CSF114(Glc)-based immunoassay on sera may have important prognostic value in monitoring MS disease progression guiding optimal therapeutic treatment.| File | Dimensione | Formato | |
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