OBJECTIVES: In the past essential thrombocythemia was considered a disease of the elderly. At present, the number of young people suffering from this disease is growing, with a slightly higher frequency in females. We investigated the effects of interferon alfa therapy in these patients. STUDY DESIGN: We describe 9 pregnancies in 4 women affected by essential thrombocythemia. RESULTS: Four pregnancies were carried out without interferon alfa therapy, and resulted in 2 intrauterine deaths, 1 spontaneous abortion, and 1 neonatal death. Interferon alfa was given during another 5 pregnancies; among them, 2 ended in preterm deliveries with normal infants, and 3 in full-term deliveries. The literature is reviewed. CONCLUSION: Our cases and published series suggest that fetal outcome is improved by therapy, and that interferon alfa may be the best therapeutic option.

Interferon alfa treatment for pregnant women affected by essential thrombocythemia: case reports and a review / Martinelli, Pasquale; Martinelli, Vincenzo; Agangi, A.; Maruotti, G.; Paladini, Dario; Ciancia, R.; Rotoli, Bruno. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - ELETTRONICO. - 191:(2004), pp. 2016-2020. [10.1016/j.ajog.2004.05.001]

Interferon alfa treatment for pregnant women affected by essential thrombocythemia: case reports and a review.

MARTINELLI, PASQUALE;MARTINELLI, VINCENZO;G. MARUOTTI;PALADINI, DARIO;ROTOLI, BRUNO
2004

Abstract

OBJECTIVES: In the past essential thrombocythemia was considered a disease of the elderly. At present, the number of young people suffering from this disease is growing, with a slightly higher frequency in females. We investigated the effects of interferon alfa therapy in these patients. STUDY DESIGN: We describe 9 pregnancies in 4 women affected by essential thrombocythemia. RESULTS: Four pregnancies were carried out without interferon alfa therapy, and resulted in 2 intrauterine deaths, 1 spontaneous abortion, and 1 neonatal death. Interferon alfa was given during another 5 pregnancies; among them, 2 ended in preterm deliveries with normal infants, and 3 in full-term deliveries. The literature is reviewed. CONCLUSION: Our cases and published series suggest that fetal outcome is improved by therapy, and that interferon alfa may be the best therapeutic option.
2004
Interferon alfa treatment for pregnant women affected by essential thrombocythemia: case reports and a review / Martinelli, Pasquale; Martinelli, Vincenzo; Agangi, A.; Maruotti, G.; Paladini, Dario; Ciancia, R.; Rotoli, Bruno. - In: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 0002-9378. - ELETTRONICO. - 191:(2004), pp. 2016-2020. [10.1016/j.ajog.2004.05.001]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/201693
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