We suggest that the low MBL activity in patients bearing the HYPD haplotype may allow enhanced bacterial colonization of the gastric mucosa and reduce down-regulation of IL-1 beta production, thereby increasing the risk of gastric cancer. Otherwise, MBL2 HYPD haplotype may be in linkage disequilibrium with variants of other genes responsible for the increased risk of gastric cancer. To conclude, the MBL2-defective HYPD haplotype may be a novel genetic marker of risk for gastric cancer in Helicobacter pylori-infected patients.
A mannose-binding lectin-defective haplotype is a risk factor for gastric cancer / Scudiero, Olga; Nardone, GERARDO ANTONIO PIO; Omodei, D.; Tatangelo, F.; Vitale, DINO FRANCO; Salvatore, Francesco; Castaldo, Giuseppe. - In: CLINICAL CHEMISTRY. - ISSN 0009-9147. - STAMPA. - 52:8(2006), pp. 1625-1627. [10.1373/clinchem.2006.071696]
A mannose-binding lectin-defective haplotype is a risk factor for gastric cancer.
SCUDIERO, OLGA;NARDONE, GERARDO ANTONIO PIO;VITALE, DINO FRANCO;SALVATORE, FRANCESCO;CASTALDO, GIUSEPPE
2006
Abstract
We suggest that the low MBL activity in patients bearing the HYPD haplotype may allow enhanced bacterial colonization of the gastric mucosa and reduce down-regulation of IL-1 beta production, thereby increasing the risk of gastric cancer. Otherwise, MBL2 HYPD haplotype may be in linkage disequilibrium with variants of other genes responsible for the increased risk of gastric cancer. To conclude, the MBL2-defective HYPD haplotype may be a novel genetic marker of risk for gastric cancer in Helicobacter pylori-infected patients.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
