The reactivity in water of a series of nucleosides and nucleotides towards ferrocenemethanol was investigated. Several adducts incorporating the ferrocenemethyl moiety into the heterocyclic base were isolated and their activity was tested against HIV-1, HBV, YFV, BVDV and several bacteria. However, none of the new compounds showed significant antiviral activity nor cytotoxicity. The reaction with ferrocenemethanol of the model dinucleotide 5′dCpdG3′, for a direct comparison of the behaviour of purine versus pyrimidine bases, is also discussed.
In-water reactivity of nucleosides and nucleotides: One-step preparation and biological evaluation of novel ferrocenyl-derivatives / DE CHAMPDORE, M.; DI FABIO, Giovanni; Messere, A.; Montesarchio, Daniela; Piccialli, Gennaro; Loddo, R.; LA COLLA, M.; LA COLLA, P.. - In: TETRAHEDRON. - ISSN 0040-4020. - ELETTRONICO. - 60:31(2004), pp. 6555-6563. [10.1016/j.tet.2004.06.013]
In-water reactivity of nucleosides and nucleotides: One-step preparation and biological evaluation of novel ferrocenyl-derivatives
DI FABIO, GIOVANNI;MONTESARCHIO, DANIELA;PICCIALLI, GENNARO;
2004
Abstract
The reactivity in water of a series of nucleosides and nucleotides towards ferrocenemethanol was investigated. Several adducts incorporating the ferrocenemethyl moiety into the heterocyclic base were isolated and their activity was tested against HIV-1, HBV, YFV, BVDV and several bacteria. However, none of the new compounds showed significant antiviral activity nor cytotoxicity. The reaction with ferrocenemethanol of the model dinucleotide 5′dCpdG3′, for a direct comparison of the behaviour of purine versus pyrimidine bases, is also discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
