A detailed analysis of the secondary metabolites of the sponge Aplysina cauliformis has been performed. Eight compounds were identified, two of which (13, 14) are new bromotyrosine derivatives whose structures were determinated from spectroscopic evidence, including 2D NMR. The new compounds were analyzed for cytotoxic activity and compound 14 was shown to inhibit mammalian protein synthesis and cell proliferation.
Chemistry of Verongida Sponges 9. Secondary Metabolite Composition of the Caribbean Sponge Aplysina cauliformis / Ciminiello, Patrizia; Dell'Aversano, Carmela; Fattorusso, Ernesto; S., Magno; M., Pansini. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - STAMPA. - 62:(1999), pp. 590-593. [10.1021/np9805138]
Chemistry of Verongida Sponges 9. Secondary Metabolite Composition of the Caribbean Sponge Aplysina cauliformis
CIMINIELLO, PATRIZIA;DELL'AVERSANO, CARMELA;FATTORUSSO, ERNESTO;
1999
Abstract
A detailed analysis of the secondary metabolites of the sponge Aplysina cauliformis has been performed. Eight compounds were identified, two of which (13, 14) are new bromotyrosine derivatives whose structures were determinated from spectroscopic evidence, including 2D NMR. The new compounds were analyzed for cytotoxic activity and compound 14 was shown to inhibit mammalian protein synthesis and cell proliferation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
