A further chemical investigation of the Caribbean marine sponge Aplysina archeri led to the isolation of a novel bromocompound, archerine (1). Its structure was established through extensive NMR spectroscopy, including 1H-13C HSQC, 1H-13C HMBC and 1H-15N HMBC experiments, as well as positive FAB MS/MS spectra. The capability of archerine to chelate zinc ions was investigated. Archerine exhibited antihistamine activity on the isolated guinea pig ileum at concentrations as low as 1 uM.
Archerine, a Novel Anti-Histaminic Bromotyrosine-Derived Compound from the Caribbean Marine Sponge Aplysina archeri / Ciminiello, Patrizia; Dell'Aversano, Carmela; Fattorusso, Ernesto; S., Magno. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - (2001), pp. 55-60.
Archerine, a Novel Anti-Histaminic Bromotyrosine-Derived Compound from the Caribbean Marine Sponge Aplysina archeri
CIMINIELLO, PATRIZIA;DELL'AVERSANO, CARMELA;FATTORUSSO, ERNESTO;
2001
Abstract
A further chemical investigation of the Caribbean marine sponge Aplysina archeri led to the isolation of a novel bromocompound, archerine (1). Its structure was established through extensive NMR spectroscopy, including 1H-13C HSQC, 1H-13C HMBC and 1H-15N HMBC experiments, as well as positive FAB MS/MS spectra. The capability of archerine to chelate zinc ions was investigated. Archerine exhibited antihistamine activity on the isolated guinea pig ileum at concentrations as low as 1 uM.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
