Atorvastatin undergoes a self-sensitized photooxygenation by sunlight in water. The main photoproducts, isolated by chromatographic techniques, have been identified by spectroscopic means. They present a lactam ring arising from an oxidation of pyrrole ring and an alkyl/aryl shift. A mechanism involving singlet oxygen addition and an epoxide intermediate is suggested.
Photochemical behavior of the drug atorvastatin in water / Cermola, Flavio; DELLA GRECA, Marina; Iesce, MARIA ROSARIA; S., Montanaro; Previtera, Lucio; Temussi, Fabio. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 62:(2006), pp. 7390-7395.
Photochemical behavior of the drug atorvastatin in water.
CERMOLA, FLAVIO;DELLA GRECA, MARINA;IESCE, MARIA ROSARIA;PREVITERA, LUCIO;TEMUSSI, FABIO
2006
Abstract
Atorvastatin undergoes a self-sensitized photooxygenation by sunlight in water. The main photoproducts, isolated by chromatographic techniques, have been identified by spectroscopic means. They present a lactam ring arising from an oxidation of pyrrole ring and an alkyl/aryl shift. A mechanism involving singlet oxygen addition and an epoxide intermediate is suggested.File in questo prodotto:
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