The aim of this work is to investigate if the optical tweezers (OT) are suitable as a diagnostic tool for monitoring the oligodeoxyribonucleotide (ODN) structural behavior in solution. Preliminary experiments, performed on the quadruplex formed by the ODN sequence TGGGGT, showed that the OT can be used as a probe for ODN structuration by monitoring the medium viscosity changes associated with ODN folding-unfolding processes.
Optical Tweezers as a probe for oligoeoxyribonucleotide structuration / Borbone, Nicola; Oliviero, Giorgia; Amato, Jussara; Piccialli, Gennaro; Mayol, Luciano; Miccio, L.; Pesce, Giuseppe; Sasso, Antonio. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 26:(2007), pp. 1295-1299. [10.1080/15257770701530541]
Optical Tweezers as a probe for oligoeoxyribonucleotide structuration
BORBONE, NICOLA;OLIVIERO, GIORGIA;AMATO, JUSSARA;PICCIALLI, GENNARO;MAYOL, LUCIANO;PESCE, GIUSEPPE;SASSO, ANTONIO
2007
Abstract
The aim of this work is to investigate if the optical tweezers (OT) are suitable as a diagnostic tool for monitoring the oligodeoxyribonucleotide (ODN) structural behavior in solution. Preliminary experiments, performed on the quadruplex formed by the ODN sequence TGGGGT, showed that the OT can be used as a probe for ODN structuration by monitoring the medium viscosity changes associated with ODN folding-unfolding processes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
