Continuing our research on the development of nucleopeptides as ODN analogs for biomedical and bioengineering applications, here we report the synthesis and the chemical–physical characterization of a homoadenine hexamer based on a l-diaminobutyric acid (l-DABA) backbone (dabPNA), and its binding studies with a complementary aegPNA. We demonstrated by CD and UV experiments that the l-dabPNA binds the aegPNA forming a complex with good thermal stability, that we identified as a left-handed triplex
Evidences for complex formation between L-dabPNA and aegPNA / Roviello, Giovanni; Musumeci, Domenica; Bucci, Enrico; Castiglione, M.; Cesarani, A.; Pedone, Carlo; Piccialli, Gennaro. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 18:17(2008), pp. 4757-4760.
Evidences for complex formation between L-dabPNA and aegPNA
ROVIELLO, GIOVANNI;MUSUMECI, DOMENICA;BUCCI, ENRICO;PEDONE, CARLO;PICCIALLI, GENNARO
2008
Abstract
Continuing our research on the development of nucleopeptides as ODN analogs for biomedical and bioengineering applications, here we report the synthesis and the chemical–physical characterization of a homoadenine hexamer based on a l-diaminobutyric acid (l-DABA) backbone (dabPNA), and its binding studies with a complementary aegPNA. We demonstrated by CD and UV experiments that the l-dabPNA binds the aegPNA forming a complex with good thermal stability, that we identified as a left-handed triplexI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
