Interferon (IFN)-beta has become a widespread therapy for multiple sclerosis. As already reported for IFN-alpha, thyroid autoimmunity and dysfunctions have been observed also in course of IFN-beta therapy. Nevertheless, very few cases of Graves' disease, occurred in such condition, have been reported in literature. We here describe the case of a 40-year-old female affected by multiple sclerosis, who received IFN-beta-1b, 8 million IU s.c. every other day for her condition. After 22 months of cytokine administration, she developed a severe Graves' disease with persistently positive TR-Ab which suggested the withdrawal of the treatment. Our patient had performed a complete thyroid evaluation with normal findings, before and during the first 6 months of therapy. This case suggests that patients undergoing long-term IFN-beta therapy should be monitored for thyroid hormones and antibodies throughout the treatment as thyroidal side effect can be a late event.

Long-term treatment with interferon-beta therapy for multiple sclerosis and occurrence of Graves' disease. J Endocrinol Invest. 2000 May;23(5):321-4 / Rotondi, M; Mazziotti, G; Biondi, Bernadette; Manganella, G; Del Buono, Ad; Montella, P; di Cristofaro, M; Di Iorio, G; Amato, G; Carella, C.. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - STAMPA. - 23:5(2000), pp. 321-324.

Long-term treatment with interferon-beta therapy for multiple sclerosis and occurrence of Graves' disease. J Endocrinol Invest. 2000 May;23(5):321-4.

BIONDI, BERNADETTE;
2000

Abstract

Interferon (IFN)-beta has become a widespread therapy for multiple sclerosis. As already reported for IFN-alpha, thyroid autoimmunity and dysfunctions have been observed also in course of IFN-beta therapy. Nevertheless, very few cases of Graves' disease, occurred in such condition, have been reported in literature. We here describe the case of a 40-year-old female affected by multiple sclerosis, who received IFN-beta-1b, 8 million IU s.c. every other day for her condition. After 22 months of cytokine administration, she developed a severe Graves' disease with persistently positive TR-Ab which suggested the withdrawal of the treatment. Our patient had performed a complete thyroid evaluation with normal findings, before and during the first 6 months of therapy. This case suggests that patients undergoing long-term IFN-beta therapy should be monitored for thyroid hormones and antibodies throughout the treatment as thyroidal side effect can be a late event.
2000
Long-term treatment with interferon-beta therapy for multiple sclerosis and occurrence of Graves' disease. J Endocrinol Invest. 2000 May;23(5):321-4 / Rotondi, M; Mazziotti, G; Biondi, Bernadette; Manganella, G; Del Buono, Ad; Montella, P; di Cristofaro, M; Di Iorio, G; Amato, G; Carella, C.. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - STAMPA. - 23:5(2000), pp. 321-324.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/336161
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