Rat thyroid cells in culture, rendered quiescent by hormone deprivation, can be stimulated to undergo DNA synthesis in the absence of serum by the addition of purified thyrotropin. The primary effect in response to thyrotropin action in thyroid cells is the induction of the c-fos oncogene, followed by c-myc expression. This suggests that thyrotropin acts as a competence growth factor.
Induction of the c-fos oncogene by thyrotropic hormone in rat thyroid cells in culture / G., Colletta; A. M., Cirafici; Vecchio, Giancarlo. - In: SCIENCE. - ISSN 0036-8075. - STAMPA. - 233:4762(1986), pp. 458-460.
Induction of the c-fos oncogene by thyrotropic hormone in rat thyroid cells in culture
VECCHIO, GIANCARLO
1986
Abstract
Rat thyroid cells in culture, rendered quiescent by hormone deprivation, can be stimulated to undergo DNA synthesis in the absence of serum by the addition of purified thyrotropin. The primary effect in response to thyrotropin action in thyroid cells is the induction of the c-fos oncogene, followed by c-myc expression. This suggests that thyrotropin acts as a competence growth factor.File in questo prodotto:
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