Hemophagocytic histiocytosis (HPS) is an idiopathic, familial or secondary syndrome characterized by mature histiocytes causing intensive erythrophagocytosis. CASE: A 2-month-old male suffering from autoimmune hemolytic anemia, fever, jaundice and hepatosplenomegalia underwent fine needle aspiration cytology of the spleen. Aspiration was performed using a 23-gauge, short needle with a subcostal approach. The smear showed a monomorphous cell population of mature histiocytes with marginal nuclei and wide, well-defined cytoplasm. The cytoplasm was microvaculated and often contained > or = 1 erythrocytes and occasional lymphocytes. Immunostaining performed on cytospin samples showed diffuse positivity for alpha-1-antichymotrypsin and S-100. Differential diagnosis with malignant histiocytosis, Langerhans histiocytosis and sinus histiocytosis with massive lymphadenopathy was established. HPS was diagnosed because of the cytologic and immunocytochemical features and clinical data. CONCLUSION: HPS may be diagnosed using fine needle aspiration of the spleen when other biopsy samples have been unsuccessful. Cytologic, diagnosis of HPS should always be considered in a specific clinical setting, because early treatment can often save the patient's life.

Hemophagocytic histiocytosis diagnosed by fine needle aspiration cytology of the spleen. A case report / Zeppa, Pio; Vetrani, Antonio; Ciancia, G; Cuccuru, A; Palombini, Lucio. - In: ACTA CYTOLOGICA. - ISSN 0001-5547. - STAMPA. - 48:3(2004), pp. 415-419.

Hemophagocytic histiocytosis diagnosed by fine needle aspiration cytology of the spleen. A case report.

ZEPPA, PIO;VETRANI, ANTONIO;PALOMBINI, LUCIO
2004

Abstract

Hemophagocytic histiocytosis (HPS) is an idiopathic, familial or secondary syndrome characterized by mature histiocytes causing intensive erythrophagocytosis. CASE: A 2-month-old male suffering from autoimmune hemolytic anemia, fever, jaundice and hepatosplenomegalia underwent fine needle aspiration cytology of the spleen. Aspiration was performed using a 23-gauge, short needle with a subcostal approach. The smear showed a monomorphous cell population of mature histiocytes with marginal nuclei and wide, well-defined cytoplasm. The cytoplasm was microvaculated and often contained > or = 1 erythrocytes and occasional lymphocytes. Immunostaining performed on cytospin samples showed diffuse positivity for alpha-1-antichymotrypsin and S-100. Differential diagnosis with malignant histiocytosis, Langerhans histiocytosis and sinus histiocytosis with massive lymphadenopathy was established. HPS was diagnosed because of the cytologic and immunocytochemical features and clinical data. CONCLUSION: HPS may be diagnosed using fine needle aspiration of the spleen when other biopsy samples have been unsuccessful. Cytologic, diagnosis of HPS should always be considered in a specific clinical setting, because early treatment can often save the patient's life.
2004
Hemophagocytic histiocytosis diagnosed by fine needle aspiration cytology of the spleen. A case report / Zeppa, Pio; Vetrani, Antonio; Ciancia, G; Cuccuru, A; Palombini, Lucio. - In: ACTA CYTOLOGICA. - ISSN 0001-5547. - STAMPA. - 48:3(2004), pp. 415-419.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/341435
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