Synthesis of noncompetitive glycosidase inhibitors L-gulo-DNJ and L-talo-DNJ has been achieved in 9-10 steps starting from Garner’s aldehyde. Key to the success of this procedure was the construction of a 2,3-unsaturated pyperidine 14, which syn dihydroxylation under Kishi’s and Donohoe’s conditions led to the desired iminosugars
Synthesis of 1-Deoxy-L-Gulonojirimycin and 1-Deoxy-L-Talonojirimycin / D'Alonzo, Daniele; Guaragna, Annalisa; Paolella, C.; Palumbo, Giovanni. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - ELETTRONICO. - 50:18(2009), pp. 2045-2047. [10.1016/j.tetlet.2009.02.111]
Synthesis of 1-Deoxy-L-Gulonojirimycin and 1-Deoxy-L-Talonojirimycin
D'ALONZO, DANIELE
;GUARAGNA, ANNALISA;C. Paolella;PALUMBO, GIOVANNI
2009
Abstract
Synthesis of noncompetitive glycosidase inhibitors L-gulo-DNJ and L-talo-DNJ has been achieved in 9-10 steps starting from Garner’s aldehyde. Key to the success of this procedure was the construction of a 2,3-unsaturated pyperidine 14, which syn dihydroxylation under Kishi’s and Donohoe’s conditions led to the desired iminosugarsFile in questo prodotto:
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