nsight into the influence of inversion of polarity sites on the structural features of quadruplex structures is presented. The NMR and CD studies concern modified oligodeoxynucleotides (ODNs) based on the quadruplex forming sequence TGGGT. The presence of inversion of polarity sites not only does not compromise the formation of quadruplexes, but in some cases it increases the thermal stability of modified complexes compared with that of the unmodified one.
Effects of the introduction of the inversion of polarity sites in the quadruplex forming oligonucleotide TGGGT / Esposito, Veronica; Virgilio, Antonella; Pepe, A.; Oliviero, Giorgia; Mayol, Luciano; Galeone, Aldo. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - STAMPA. - 17:5(2009), pp. 1997-2001. [10.1016/j.bmc.2009.01.027]
Effects of the introduction of the inversion of polarity sites in the quadruplex forming oligonucleotide TGGGT.
ESPOSITO, VERONICA;VIRGILIO, ANTONELLA;OLIVIERO, GIORGIA;MAYOL, LUCIANO;GALEONE, ALDO
2009
Abstract
nsight into the influence of inversion of polarity sites on the structural features of quadruplex structures is presented. The NMR and CD studies concern modified oligodeoxynucleotides (ODNs) based on the quadruplex forming sequence TGGGT. The presence of inversion of polarity sites not only does not compromise the formation of quadruplexes, but in some cases it increases the thermal stability of modified complexes compared with that of the unmodified one.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
