The chemical investigation of Azorean nudibranch mollusk Tambja ceutae led us to isolate a new member of the tambjamine family, tambjamine K (1). The bryozoan Bugula dentata, prey of the nudibranch, was also analyzed and found to contain compound 1 in very small amounts together with known blue pigment 2 and tambjamines A (3) and B (4). The structure of tambjamine 1 was elucidated by the interpretation of the spectroscopic data as well as by the comparison with related compounds. Compounds 1 and 2 possess antiproliferative activity, in particular, tambjamine K (1) displayed high cytotoxicity against both tumor and non-tumor mammalian cells.
A new cytotoxic tambjamine alkaloid from the Azorean nudibranch Tambja ceutae / M., Carbone; Irace, Carlo; F., Costagliola; F., Castelluccio; G., Villani; G., Calado; V., Padula; G., Cimino; J., Lucas Cervera; Santamaria, Rita; M., Gavagnin. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - STAMPA. - 20:8(2010), pp. 2668-2670. [10.1016/j.bmcl.2010.02.020]
A new cytotoxic tambjamine alkaloid from the Azorean nudibranch Tambja ceutae
IRACE, CARLO;SANTAMARIA, RITA;
2010
Abstract
The chemical investigation of Azorean nudibranch mollusk Tambja ceutae led us to isolate a new member of the tambjamine family, tambjamine K (1). The bryozoan Bugula dentata, prey of the nudibranch, was also analyzed and found to contain compound 1 in very small amounts together with known blue pigment 2 and tambjamines A (3) and B (4). The structure of tambjamine 1 was elucidated by the interpretation of the spectroscopic data as well as by the comparison with related compounds. Compounds 1 and 2 possess antiproliferative activity, in particular, tambjamine K (1) displayed high cytotoxicity against both tumor and non-tumor mammalian cells.| File | Dimensione | Formato | |
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