Cytotoxic T lymphocytes (CTLs) are an essential component of the immune defense against many virus infections. CTLs recognize viral peptides in the context of the major histocompatibility complex (MHC) class I molecules on the surface of infected cells. Many viruses have evolved mechanisms to interfere with MHC class I expression as a means of evading the host immune response. In the present research we have studied the effect of in vitro Feline Herpesvirus 1 (FeHV-1) infection on MHC class I expression. The results of this study demonstrate that FeHV-1 down regulates surface expression of MHC class I molecules on infected cells, presumably to evade cytotoxic T-cell recognition and, perhaps, attenuate induction of immunity. Sensitivity to UV irradiation and insensitivity to a viral DNA synthesis inhibitor, like phosphonacetic acid, revealed that immediate early or early viral gene(s) are responsible. Use of the protein translation inhibitor cycloheximide confirmed that an early gene is primarily responsible

Feline Herpesvirus-1 Down-Regulates MHC Class I Expression in an Homologous Cell System / Montagnaro, Serena; Longo, Mariangela; Pacilio, M; Indovina, P; Roberti, A; DE MARTINO, Luisa; Iovane, Giuseppe; Pagnini, Ugo. - In: JOURNAL OF CELLULAR BIOCHEMISTRY. - ISSN 0730-2312. - STAMPA. - 106:1(2009), pp. 179-185. [10.1002/jcb.21986]

Feline Herpesvirus-1 Down-Regulates MHC Class I Expression in an Homologous Cell System

MONTAGNARO, SERENA;LONGO, MARIANGELA;DE MARTINO, LUISA;IOVANE, GIUSEPPE;PAGNINI, UGO
2009

Abstract

Cytotoxic T lymphocytes (CTLs) are an essential component of the immune defense against many virus infections. CTLs recognize viral peptides in the context of the major histocompatibility complex (MHC) class I molecules on the surface of infected cells. Many viruses have evolved mechanisms to interfere with MHC class I expression as a means of evading the host immune response. In the present research we have studied the effect of in vitro Feline Herpesvirus 1 (FeHV-1) infection on MHC class I expression. The results of this study demonstrate that FeHV-1 down regulates surface expression of MHC class I molecules on infected cells, presumably to evade cytotoxic T-cell recognition and, perhaps, attenuate induction of immunity. Sensitivity to UV irradiation and insensitivity to a viral DNA synthesis inhibitor, like phosphonacetic acid, revealed that immediate early or early viral gene(s) are responsible. Use of the protein translation inhibitor cycloheximide confirmed that an early gene is primarily responsible
2009
Feline Herpesvirus-1 Down-Regulates MHC Class I Expression in an Homologous Cell System / Montagnaro, Serena; Longo, Mariangela; Pacilio, M; Indovina, P; Roberti, A; DE MARTINO, Luisa; Iovane, Giuseppe; Pagnini, Ugo. - In: JOURNAL OF CELLULAR BIOCHEMISTRY. - ISSN 0730-2312. - STAMPA. - 106:1(2009), pp. 179-185. [10.1002/jcb.21986]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/374547
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