Spirocurcasone (14), a diterpenoid possessing the unprecedented "spirorhamnofolane" skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was established using HRESIMS, NMR, and quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum. Some of the isolated diterpenoids showed a potent activity against L5178Y, a mouse lymphoma cell line.
Spirocurcasone, a Diterpenoid with a novel carbon skeleton from Jatropha curcas / Chianese, Giuseppina; Fattorusso, Ernesto; O. O., Aiyelaagbe; Luciano, Paolo; H. C., Schroder; W. E., Muller; TAGLIALATELA SCAFATI, Orazio. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 13:(2011), pp. 316-319. [10.1021/ol102802u]
Spirocurcasone, a Diterpenoid with a novel carbon skeleton from Jatropha curcas
CHIANESE, GIUSEPPINA;FATTORUSSO, ERNESTO;LUCIANO, PAOLO;TAGLIALATELA SCAFATI, ORAZIO
2011
Abstract
Spirocurcasone (14), a diterpenoid possessing the unprecedented "spirorhamnofolane" skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was established using HRESIMS, NMR, and quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum. Some of the isolated diterpenoids showed a potent activity against L5178Y, a mouse lymphoma cell line.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
