A metabolic imbalance between anabolic drive and catabolic forces is commonly observed in chronic heart failure (CHF) patients, with the latter prevailing over anabolic hormones. Moreover, anabolic deficiencies are independent markers of poor prognosis. This finding represents a solid background for the implementation of therapeutic trials based on replacement therapy. The somatotropic axis (GH/IGF-1) is the most powerful anabolic axis of the body and its decline is related with a poor outcome and a worse clinical status. Growth hormone (GH) administration may enter the therapeutic arena as adjunctive treatment in patients affected by CHF and GH/IGF-1 deficiency. The T.O.S.CA. project aims at investigating the relationship between CHF and hormonal deficiency.
Anabolic/catabolic imbalance in chronic heart failure / Cittadini, Antonio; Bossone, E.; Marra, ALBERTO MARIA; Arcopinto, Michele; Bobbio, E.; Longobardi, S.; Cevara, C.; Di Michele, S.; Sacca', Luigi. - In: MONALDI ARCHIVES FOR CHEST DISEASE. - ISSN 1122-0643. - STAMPA. - 74:2(2010), pp. 53-56. [10.4081/monaldi.2010.266]
Anabolic/catabolic imbalance in chronic heart failure
CITTADINI, ANTONIO;Bossone E.;MARRA, ALBERTO MARIA;ARCOPINTO, MICHELE;SACCA', LUIGI
2010
Abstract
A metabolic imbalance between anabolic drive and catabolic forces is commonly observed in chronic heart failure (CHF) patients, with the latter prevailing over anabolic hormones. Moreover, anabolic deficiencies are independent markers of poor prognosis. This finding represents a solid background for the implementation of therapeutic trials based on replacement therapy. The somatotropic axis (GH/IGF-1) is the most powerful anabolic axis of the body and its decline is related with a poor outcome and a worse clinical status. Growth hormone (GH) administration may enter the therapeutic arena as adjunctive treatment in patients affected by CHF and GH/IGF-1 deficiency. The T.O.S.CA. project aims at investigating the relationship between CHF and hormonal deficiency.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
