Two unprecedented cyclic peptides, solomonamides A and B, were isolated from the marine sponge Theonella swinhoei. The structures were elucidated on the basis of comprehensive 1D and 2D NMR analysis and high-resolution mass spectrometry. A combined approach, involving Marfey’s method, QM J based analysis, and DFT J/13C calculations, was used for establishing the absolute configuration of the entire molecule. Solomonamide A showed in vivo anti-inflammatory activity.
Solomonamides A and B, new anti-inflammatory peptides from Theonella swinhoei / Festa, C., De Marino, S., Sepe, V., D'Auria, M.V., Bifulco, G., Debitus, C., Bucci, M., Vellecco, V., Zampella, A.. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 13:6(2011), pp. 1532-1535. [10.1021/ol200221n]
Solomonamides A and B, new anti-inflammatory peptides from Theonella swinhoei
Festa Carmen;De Marino S.;Sepe V.;D'Auria M. V.;Bucci M.;Vellecco V.;Zampella A.
2011
Abstract
Two unprecedented cyclic peptides, solomonamides A and B, were isolated from the marine sponge Theonella swinhoei. The structures were elucidated on the basis of comprehensive 1D and 2D NMR analysis and high-resolution mass spectrometry. A combined approach, involving Marfey’s method, QM J based analysis, and DFT J/13C calculations, was used for establishing the absolute configuration of the entire molecule. Solomonamide A showed in vivo anti-inflammatory activity.| File | Dimensione | Formato | |
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Org. Lett., 2011, 13, 1532-1535.pdf
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