A monoclonal antibody (MoAb), UN-1, specific for a human thymocyte cell surface antigen was produced. The same MoAb recognized in immunofluorescence also cells of the human T line HPB-ALL, while did not bind human peripheral blood cells and cells of some T, B and myeloid lines. Western blotting analysis of thymocyte membranes with MoAb UN-1 revealed a structure with a molecular weight of 150 kDa. Therefore both the pattern of expression and the size of the antigen recognized by MoAb UN-1 did not correspond to any previously described cell surface molecule.
UN-1, a murine monoclonal antibody recognizing a human thymocyte undescribed antigen / Tassone, P.; Bond, H.; Bonelli, P.; Tuccillo, F.; Cecco, L.; Lamberti, Annalisa; De Lorenzo, F.; Cerra, M.; Turco, M. C.; Venuta, S.. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 26:(1992), pp. 128-129.
UN-1, a murine monoclonal antibody recognizing a human thymocyte undescribed antigen
LAMBERTI, ANNALISA;
1992
Abstract
A monoclonal antibody (MoAb), UN-1, specific for a human thymocyte cell surface antigen was produced. The same MoAb recognized in immunofluorescence also cells of the human T line HPB-ALL, while did not bind human peripheral blood cells and cells of some T, B and myeloid lines. Western blotting analysis of thymocyte membranes with MoAb UN-1 revealed a structure with a molecular weight of 150 kDa. Therefore both the pattern of expression and the size of the antigen recognized by MoAb UN-1 did not correspond to any previously described cell surface molecule.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
