Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded two known and three new C-4 norcembranoids, named chloroscabrolides A (3) and B (4) and prescabrolide (5). Chloroscabrolide A is a pentacyclic norcembranoid including an unprecedented THF-type ring to connect C-13 and C-15; furthermore, it is only the second chlorinated cembranoid derivative to be reported in the literature. The relative configuration of chloroscabrolide A has been established on the basis of a comparison between experimental 13C NMR data and DFT-calculated 13C NMR chemical shifts. All the isolated norcembranoids have been evaluated for iNOS protein inhibition.
Chloroscabrolides, chlorinated norcembranoids from the Indonesian soft coral Sinularia sp / Fattorusso, Ernesto; Luciano, Paolo; M. Y., Putra; TAGLIALATELA SCAFATI, Orazio; Ianaro, Angela; Panza, Elisabetta; G., Bavestrello; C., Cerrano. - In: TETRAHEDRON. - ISSN 0040-4020. - 67:(2011), pp. 7983-7988. [10.1016/j.tet.2011.08.024]
Chloroscabrolides, chlorinated norcembranoids from the Indonesian soft coral Sinularia sp.
FATTORUSSO, ERNESTO;LUCIANO, PAOLO;TAGLIALATELA SCAFATI, ORAZIO;IANARO, ANGELA;PANZA, ELISABETTA;
2011
Abstract
Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded two known and three new C-4 norcembranoids, named chloroscabrolides A (3) and B (4) and prescabrolide (5). Chloroscabrolide A is a pentacyclic norcembranoid including an unprecedented THF-type ring to connect C-13 and C-15; furthermore, it is only the second chlorinated cembranoid derivative to be reported in the literature. The relative configuration of chloroscabrolide A has been established on the basis of a comparison between experimental 13C NMR data and DFT-calculated 13C NMR chemical shifts. All the isolated norcembranoids have been evaluated for iNOS protein inhibition.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
