In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC(50) value of 6 nM.
Swinholide J, a potent cytotoxin from the marine sponge Theonella swinhoei / De Marino, S.; Festa, Carmen; D'Auria, M. V.; Cresteil, T.; Debitus, C.; Zampella, A.. - In: MARINE DRUGS. - ISSN 1660-3397. - 9:6(2011), pp. 1133-1141. [10.3390/md9061133]
Swinholide J, a potent cytotoxin from the marine sponge Theonella swinhoei
De Marino S.;Festa Carmen;D'Auria M. V.;Zampella A.
2011
Abstract
In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC(50) value of 6 nM.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
