The transcription factor Nkx2-1 (also known as TTF-1, Titf1 or T/EBP) contains two apparently redundant activation domains and is post-translationally modified by phosphorylation. We have generated mouse mutant strains to assess the roles of the two activation domains and of phosphorylation in mouse development and differentiation.

In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1 / D., Silberschmidt; A., Rodriguez Mallon; P., Mithboakar; G., Calì; Amendola, Elena; R., Sanges; M., Zannini; M., Scarfò; P., De Luca; Nitsch, Lucio; DI LAURO, Roberto; DE FELICE, Mario. - In: BMC DEVELOPMENTAL BIOLOGY. - ISSN 1471-213X. - 11:9(2011), pp. 1-16. [10.1186/1471-213X-11-9]

In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1

AMENDOLA, Elena;NITSCH, LUCIO;DI LAURO, ROBERTO;DE FELICE, MARIO
2011

Abstract

The transcription factor Nkx2-1 (also known as TTF-1, Titf1 or T/EBP) contains two apparently redundant activation domains and is post-translationally modified by phosphorylation. We have generated mouse mutant strains to assess the roles of the two activation domains and of phosphorylation in mouse development and differentiation.
2011
In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1 / D., Silberschmidt; A., Rodriguez Mallon; P., Mithboakar; G., Calì; Amendola, Elena; R., Sanges; M., Zannini; M., Scarfò; P., De Luca; Nitsch, Lucio; DI LAURO, Roberto; DE FELICE, Mario. - In: BMC DEVELOPMENTAL BIOLOGY. - ISSN 1471-213X. - 11:9(2011), pp. 1-16. [10.1186/1471-213X-11-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/404066
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