The solid-phase synthesis of the first example of a new diphosphate AICAR deriv. is reported. The new substance is characterized by the presence of a 5'-phosphate group while a second phosphate moiety is installed on a 5-hydroxypentyl chain attached to the 4-N-position of AICAR. Cyclization of the diphosphate deriv. by pyrophosphate bond formation allowed for the formation of a novel AICAR-based cyclic ADP-ribose (cADPR) mimic.
Solid-phase synthesis of a new diphosphate 5-aminoimidazole-4-carboxamide riboside (AICAR) derivative and studies toward cyclic AICAR diphosphate ribose / D'Errico, Stefano; Oliviero, Giorgia; Borbone, Nicola; Amato, Jussara; Piccialli, Vincenzo; Varra, Michela; Mayol, Luciano; Piccialli, Gennaro. - In: MOLECULES. - ISSN 1420-3049. - 16:(2011), pp. 8110-8118. [10.3390/molecules16098110]
Solid-phase synthesis of a new diphosphate 5-aminoimidazole-4-carboxamide riboside (AICAR) derivative and studies toward cyclic AICAR diphosphate ribose
D'ERRICO, STEFANO;OLIVIERO, GIORGIA;BORBONE, NICOLA;AMATO, JUSSARA;PICCIALLI, VINCENZO;VARRA, MICHELA;MAYOL, LUCIANO;PICCIALLI, GENNARO
2011
Abstract
The solid-phase synthesis of the first example of a new diphosphate AICAR deriv. is reported. The new substance is characterized by the presence of a 5'-phosphate group while a second phosphate moiety is installed on a 5-hydroxypentyl chain attached to the 4-N-position of AICAR. Cyclization of the diphosphate deriv. by pyrophosphate bond formation allowed for the formation of a novel AICAR-based cyclic ADP-ribose (cADPR) mimic.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
