Two new jaspamide derivs., jaspamide B (I) and jaspamide C (II), along with jaspamide have been isolated from the marine sponge Jaspis splendans collected in Vanuatu. Their chem. structures were detd. from 1- and 2-dimensional NMR studies and mass spectral data. I and II inhibited the in vitro growth of the NSCLC-N6 human tumor cell lines with IC50 values in the mg/mL range.
New jaspamide derivatives from the marine sponge Jaspis splendans collected in Vanuatu / Zampella, Angela; Giannini, C.; Debitus, C.; Roussakis, C.; D'Auria, MARIA VALERIA. - In: JOURNAL OF NATURAL PRODUCTS. - ISSN 0163-3864. - STAMPA. - 62:2(1999), pp. 332-334. [10.1021/np9803225]
New jaspamide derivatives from the marine sponge Jaspis splendans collected in Vanuatu
ZAMPELLA, ANGELA;D'AURIA, MARIA VALERIA
1999
Abstract
Two new jaspamide derivs., jaspamide B (I) and jaspamide C (II), along with jaspamide have been isolated from the marine sponge Jaspis splendans collected in Vanuatu. Their chem. structures were detd. from 1- and 2-dimensional NMR studies and mass spectral data. I and II inhibited the in vitro growth of the NSCLC-N6 human tumor cell lines with IC50 values in the mg/mL range.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
