Objective: To evaluate the early rate of change of best-corrected visual acuity (BCVA), central retinal sensitivity, neuroretinal and choroidal thickness in patients with macular edema after 1.25 mg/0.05 ml intravitreal bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA). Methods: A prospective, nonrandomized, interventional study. Thirty-seven consecutive eyes with macular edema were included in the study. For all eyes, BCVA, central retinochoroidal thickness at standardized A-scan, central retinal thickness, and central retinal sensitivity recorded with a spectral scanning laser ophthalmoscope optical coherence tomography/microperimeter device were evaluated at baseline and 7, 15, 30, 37, 45, and 60 days after initial treatment. All patients received 2 intravitreal bevacizumab injections at 1-month interval. Results: A significant although not related improvement of BCVA and retinal sensitivity was seen after 1 month and 2 months of follow-up. Anatomic improvement only involved the neuroretina, although significant changes of central choroidal thickness were not detected. Conclusion: Intravitreal bevacizumab for macular edema determines significant early functional and anatomic improvements.

Bevacizumab in macular edema: functional and anatomic changes in a prospective case series / Forte, R; Cennamo, G; Vecchio, Ec; Tenore, R; Aufiero, B; DE CRECCHIO, Giuseppe. - In: RETINA. - ISSN 0275-004X. - STAMPA. - 29:(2009), pp. 941-948.

Bevacizumab in macular edema: functional and anatomic changes in a prospective case series.

DE CRECCHIO, GIUSEPPE
2009

Abstract

Objective: To evaluate the early rate of change of best-corrected visual acuity (BCVA), central retinal sensitivity, neuroretinal and choroidal thickness in patients with macular edema after 1.25 mg/0.05 ml intravitreal bevacizumab (Avastin; Genentech, Inc., South San Francisco, CA). Methods: A prospective, nonrandomized, interventional study. Thirty-seven consecutive eyes with macular edema were included in the study. For all eyes, BCVA, central retinochoroidal thickness at standardized A-scan, central retinal thickness, and central retinal sensitivity recorded with a spectral scanning laser ophthalmoscope optical coherence tomography/microperimeter device were evaluated at baseline and 7, 15, 30, 37, 45, and 60 days after initial treatment. All patients received 2 intravitreal bevacizumab injections at 1-month interval. Results: A significant although not related improvement of BCVA and retinal sensitivity was seen after 1 month and 2 months of follow-up. Anatomic improvement only involved the neuroretina, although significant changes of central choroidal thickness were not detected. Conclusion: Intravitreal bevacizumab for macular edema determines significant early functional and anatomic improvements.
2009
Bevacizumab in macular edema: functional and anatomic changes in a prospective case series / Forte, R; Cennamo, G; Vecchio, Ec; Tenore, R; Aufiero, B; DE CRECCHIO, Giuseppe. - In: RETINA. - ISSN 0275-004X. - STAMPA. - 29:(2009), pp. 941-948.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/418870
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