The toxicity of many chemicals is due to their metabolic activation by CYP2E1 and other P450 enzymes. The assessment of an individual's CYP2E1 phenotype and genotype, therefore, is important to assess his/her susceptibility to many occupational and environmental pollutants. The article discusses the factors involved in CYP2E1 variability including polymorphism.
Chytochrome CYP2E1 phenotyping and genotyping in the evaluation of health risks from exposure to polluted environments / Lucas, D.; Ferrara, R.; Gonzales, E.; Albores, A.; Manno, Maurizio; Berthou, F.. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - STAMPA. - 124:1-3(2001), pp. 71-81.
Chytochrome CYP2E1 phenotyping and genotyping in the evaluation of health risks from exposure to polluted environments.
MANNO, MAURIZIO;
2001
Abstract
The toxicity of many chemicals is due to their metabolic activation by CYP2E1 and other P450 enzymes. The assessment of an individual's CYP2E1 phenotype and genotype, therefore, is important to assess his/her susceptibility to many occupational and environmental pollutants. The article discusses the factors involved in CYP2E1 variability including polymorphism.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
