The straightforward design of a new library of chiral ligands (elpanphos) based on β-1,2-D-glucodiamine is described, which represents the enantiomeric counterpart of the naplephos library. In this guise, two representative ligands have been successfully applied in the Pd-catalyzed desymmetrization of meso-cyclopent-2-ene-1,4-diol, which leads to the expected enantiomer within short times and with high ees in both traditional and unconventional solvents.
Naplephos through the looking-glass: chiral bis(phosphanylamides) based on β-1,2-D-glucodiamine and their application in enantioselective allylic substitutions / V., Benessere; A., De Roma; R., Del Litto; Lega, Matteo; Ruffo, Francesco. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - (2011), pp. 5779-5782. [10.1002/ejoc.201100960]
Naplephos through the looking-glass: chiral bis(phosphanylamides) based on β-1,2-D-glucodiamine and their application in enantioselective allylic substitutions
LEGA, MATTEO;RUFFO, FRANCESCO
2011
Abstract
The straightforward design of a new library of chiral ligands (elpanphos) based on β-1,2-D-glucodiamine is described, which represents the enantiomeric counterpart of the naplephos library. In this guise, two representative ligands have been successfully applied in the Pd-catalyzed desymmetrization of meso-cyclopent-2-ene-1,4-diol, which leads to the expected enantiomer within short times and with high ees in both traditional and unconventional solvents.| File | Dimensione | Formato | |
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