A review, with 69 refs. No longer dismissed as just a mere curiosity in the family of melanin pigments, neuromelanin is attracting increasing interest as a central constituent of certain populations of dopaminergic neurons in the human substantia nigra, which may hold the key for the understanding of neuron functioning and degeneration in aging and in Parkinson's disease. It is the purpose of this article to provide a concise review of the most significant data on the origin, structure, and functional significance of neuromelanin that accrued over the past few years. It also aims at critically surveying the currently debated views regarding the role of such intriguing pigment in the etiol. and biochem. pathol. of Parkinson's disease.
Biosynthesis, structure, and function of neuromelanin and its relation to Parkinson's disease: a critical update / D'Ischia, Marco; Prota, Giuseppe. - In: PIGMENT CELL RESEARCH. - ISSN 0893-5785. - STAMPA. - 10:(1997), pp. 370-376. [10.1111/j.1600-0749.1997.tb00694.x]
Biosynthesis, structure, and function of neuromelanin and its relation to Parkinson's disease: a critical update
D'ISCHIA, MARCO;PROTA, GIUSEPPE
1997
Abstract
A review, with 69 refs. No longer dismissed as just a mere curiosity in the family of melanin pigments, neuromelanin is attracting increasing interest as a central constituent of certain populations of dopaminergic neurons in the human substantia nigra, which may hold the key for the understanding of neuron functioning and degeneration in aging and in Parkinson's disease. It is the purpose of this article to provide a concise review of the most significant data on the origin, structure, and functional significance of neuromelanin that accrued over the past few years. It also aims at critically surveying the currently debated views regarding the role of such intriguing pigment in the etiol. and biochem. pathol. of Parkinson's disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
