Nicotine, the main alkaloid of tobacco, is a non-prescription drug to which all members of a tobacco-smoking society are exposed either through direct smoke inhalation or through second-hand passive 'smoking'. Nicotine is also commercially available in some pharmaceutical products and is used worldwide as a botanical insecticide in agriculture. Nicotine dynamics in indoor and outdoor environments as well as the human excretions and the manufacturing process are responsible for its entry in the environment through municipal and industrial wastewater discharges. The presence of nicotine in surface and ground waters points out that it survives a conventional treatment process and persists in potable-water supplies. Complete removal of nicotine is instead reported when additional chlorination steps are used. In this paper a simulation of STP chlorination of nicotine and a genotoxic evaluation of its main degradation products are reported. Under laboratory conditions removal of nicotine seems not to be due to mineralization but to transformation in oxidized and chlorinated products. The by-products have been isolated after fractionation by diverse chromatographic procedures and their structures determined using mass spectrometry and H-1 and C-13 NMR spectroscopy. Preliminary genotoxic SOS Chromotests with Escherichia coil PQ37 evidence no toxicity of the products. (C) 2012 Elsevier B.V. All rights reserved.

Chemical fate and genotoxic risk associated with hypochlorite treatment of nicotine / Zarrelli, Armando; DELLA GRECA, Marina; Parolisi, A.; Iesce, MARIA ROSARIA; Cermola, Flavio; Temussi, Fabio; Isidori, M.; Lavorgna, Marino; Passananti, Monica; Previtera, Lucio. - In: SCIENCE OF THE TOTAL ENVIRONMENT. - ISSN 0048-9697. - 426:-(2012), pp. 132-138. [10.1016/j.scitotenv.2012.03.047]

Chemical fate and genotoxic risk associated with hypochlorite treatment of nicotine

ZARRELLI, ARMANDO;DELLA GRECA, MARINA;IESCE, MARIA ROSARIA;CERMOLA, FLAVIO;TEMUSSI, FABIO;LAVORGNA, Marino;PASSANANTI, MONICA;PREVITERA, LUCIO
2012

Abstract

Nicotine, the main alkaloid of tobacco, is a non-prescription drug to which all members of a tobacco-smoking society are exposed either through direct smoke inhalation or through second-hand passive 'smoking'. Nicotine is also commercially available in some pharmaceutical products and is used worldwide as a botanical insecticide in agriculture. Nicotine dynamics in indoor and outdoor environments as well as the human excretions and the manufacturing process are responsible for its entry in the environment through municipal and industrial wastewater discharges. The presence of nicotine in surface and ground waters points out that it survives a conventional treatment process and persists in potable-water supplies. Complete removal of nicotine is instead reported when additional chlorination steps are used. In this paper a simulation of STP chlorination of nicotine and a genotoxic evaluation of its main degradation products are reported. Under laboratory conditions removal of nicotine seems not to be due to mineralization but to transformation in oxidized and chlorinated products. The by-products have been isolated after fractionation by diverse chromatographic procedures and their structures determined using mass spectrometry and H-1 and C-13 NMR spectroscopy. Preliminary genotoxic SOS Chromotests with Escherichia coil PQ37 evidence no toxicity of the products. (C) 2012 Elsevier B.V. All rights reserved.
2012
Chemical fate and genotoxic risk associated with hypochlorite treatment of nicotine / Zarrelli, Armando; DELLA GRECA, Marina; Parolisi, A.; Iesce, MARIA ROSARIA; Cermola, Flavio; Temussi, Fabio; Isidori, M.; Lavorgna, Marino; Passananti, Monica; Previtera, Lucio. - In: SCIENCE OF THE TOTAL ENVIRONMENT. - ISSN 0048-9697. - 426:-(2012), pp. 132-138. [10.1016/j.scitotenv.2012.03.047]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/467825
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