Inhibition of Macrophage Phagocytic-activity By Sv-IV, A Major Protein Secreted From the Rat Seminal-vesicle Epithelium

The protein SV-IV, one of the major secretory proteins produced by the rat sem¬inal vesicle epithelium, has been found to possess a marked ability to inhibit in vitro the phagocytic properties of activated peritoneal rat macrophages, by a mechanism that apparently involves phagocytes and target cells. Although SV-IV is a substrate for transglutaminase (TGase), an enzyme secreted by activated macrophages, TGase does not seem to play any significant role either in the binding of the protein to the cells participating in the phagocytic process or in the inhibition of macrophage pha¬gocytosis by SV-IV. The significance of the findings in relation to the reproductive process and their possible clinical implications are discussed.