The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV-IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell-to-cell contact interactions, The expression of HLA DR on Raji cells has a modulatory effect on the SV-IV-induced cytotoxic activity, The experimental evidence strongly suggests that the cytotoxic effector cells are functionally activated NK cells. (C) 1997 Wiley-Liss, Inc.
SV-IV, a major protein secreted from rat seminal vesicle epithelium, promotes lymphocyte cytotoxic activity against the lymphoblastoid Raji cell line in human peripheral blood mononuclear cells / G., Peluso; M., Marchese; A., Furgi; M., Ranieri; S. R., Spena; G., Ravagnan; M. P., Fuggetta; Porta, Raffaele; V., Metafora; S., Metafora. - In: INTERNATIONAL JOURNAL OF CANCER. - ISSN 0020-7136. - STAMPA. - 72:(1997), pp. 321-328. [10.1002/(SICI)1097-0215(19970717)72:2<321]
SV-IV, a major protein secreted from rat seminal vesicle epithelium, promotes lymphocyte cytotoxic activity against the lymphoblastoid Raji cell line in human peripheral blood mononuclear cells
PORTA, RAFFAELE;
1997
Abstract
The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV-IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell-to-cell contact interactions, The expression of HLA DR on Raji cells has a modulatory effect on the SV-IV-induced cytotoxic activity, The experimental evidence strongly suggests that the cytotoxic effector cells are functionally activated NK cells. (C) 1997 Wiley-Liss, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.