A young Italian woman with a POEMS syndrome is described. The patient had a plasma cell dyscrasia without clinical or laboratory evidence of multiple myeloma. The phenotypic analysis of bone marrow cells and peripheral blood lymphocytes revealed a normal pattern. The immunological study of CSF showed high levels of interleukin-6, whereas this cytokine was not detectable in the serum. Electrophysiological studies and sural nerve biopsy showed a mixed, demyelinating-axonal sensorimotor neuropathy with marked loss of large myelinated fibres. long-term treatment with prednisone gave some clinical improvement.

Poems Syndrome - Clinical, Pathological and Immunological Study of A Case / G., Orefice; V. B., Morra; DE MICHELE, Giuseppe; C., Fusco; Borgia, Guglielmo; R., Cerini; F., Barbieri. - In: NEUROLOGICAL RESEARCH. - ISSN 0161-6412. - STAMPA. - 16:(1994), pp. 477-480.

Poems Syndrome - Clinical, Pathological and Immunological Study of A Case

DE MICHELE, GIUSEPPE;BORGIA, GUGLIELMO;
1994

Abstract

A young Italian woman with a POEMS syndrome is described. The patient had a plasma cell dyscrasia without clinical or laboratory evidence of multiple myeloma. The phenotypic analysis of bone marrow cells and peripheral blood lymphocytes revealed a normal pattern. The immunological study of CSF showed high levels of interleukin-6, whereas this cytokine was not detectable in the serum. Electrophysiological studies and sural nerve biopsy showed a mixed, demyelinating-axonal sensorimotor neuropathy with marked loss of large myelinated fibres. long-term treatment with prednisone gave some clinical improvement.
1994
Poems Syndrome - Clinical, Pathological and Immunological Study of A Case / G., Orefice; V. B., Morra; DE MICHELE, Giuseppe; C., Fusco; Borgia, Guglielmo; R., Cerini; F., Barbieri. - In: NEUROLOGICAL RESEARCH. - ISSN 0161-6412. - STAMPA. - 16:(1994), pp. 477-480.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/483346
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