Follicular thyroid adenomas are epithelial tumors characterized by subgroups with specific chromosomal aberrations. Here we present a case with translocation t(1;6)(p35;p21). In 1p35 and 6p21, two genes of the high- mobility group of proteins are located. With P1-derived Artificial Chromosome (PACs) derived from the HMG17 gene located at 1p35 and HMG1(Y) located at 6p21, fluorescence in situ hybridization was performed. The breakpoints were located distal to HMG17 and proximal to HMG1(Y), but no rearrangement of the genes was shown by FISH. However, an overexpression of the HMG1(Y) gene was detected by RT-PCR as well as by immunohistochemistry techniques. This suggests a breakpoint in the proximity of the HMG1(Y) deregulating HMG1(Y) gene expression, a situation found in a variety of human benign mesenchymal tumors with involvement of chromosome band 6p21.
Involvement of the HMGI(Y) gene in a microfollicular adenoma of the thyroid / P. D., Cin; Fusco, Alfredo; G., Belge; G., Chiappetta; M., Fedele; P., Pauwels; R., Bullerdiek; H. V., Den. - In: GENES, CHROMOSOMES & CANCER. - ISSN 1045-2257. - STAMPA. - 24:(1999), pp. 286-289.
Involvement of the HMGI(Y) gene in a microfollicular adenoma of the thyroid
FUSCO, ALFREDO;
1999
Abstract
Follicular thyroid adenomas are epithelial tumors characterized by subgroups with specific chromosomal aberrations. Here we present a case with translocation t(1;6)(p35;p21). In 1p35 and 6p21, two genes of the high- mobility group of proteins are located. With P1-derived Artificial Chromosome (PACs) derived from the HMG17 gene located at 1p35 and HMG1(Y) located at 6p21, fluorescence in situ hybridization was performed. The breakpoints were located distal to HMG17 and proximal to HMG1(Y), but no rearrangement of the genes was shown by FISH. However, an overexpression of the HMG1(Y) gene was detected by RT-PCR as well as by immunohistochemistry techniques. This suggests a breakpoint in the proximity of the HMG1(Y) deregulating HMG1(Y) gene expression, a situation found in a variety of human benign mesenchymal tumors with involvement of chromosome band 6p21.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
