Administering a light dose of 90 J/cm(2) at 599 nm during incubation with hypericin to a highly differentiated normal epithelial cell line (FRTL-5), derived from Fisher rat thyroid, and to a neoplastic cell line (MPTK-6), derived from the lung metastases of a thyroid carcinoma induced in Fisher rats, produces cell kill at drug doses 1000 times lower than those necessary to cause the same mortality in the dark. The photocytocidal activity of this polycyclic quinone drag on neoplastic cells is superior to that of antitumor anthraquinone drugs, such as daunomycin and mitoxanthrone, and to the photosensitized antiviral activity previously reported for hypericin.
Laser Photosensitization of Cells By Hypericin / A., Andreoni; A., Colasanti; P., Colasanti; M., Mastrocinque; Riccio, Patrizia; Roberti, Giuseppe. - In: PHOTOCHEMISTRY AND PHOTOBIOLOGY. - ISSN 0031-8655. - STAMPA. - 59:(1994), pp. 529-533. [10.1111/j.1751-1097.1994.tb02978.x]
Laser Photosensitization of Cells By Hypericin
RICCIO, PATRIZIA;ROBERTI, GIUSEPPE
1994
Abstract
Administering a light dose of 90 J/cm(2) at 599 nm during incubation with hypericin to a highly differentiated normal epithelial cell line (FRTL-5), derived from Fisher rat thyroid, and to a neoplastic cell line (MPTK-6), derived from the lung metastases of a thyroid carcinoma induced in Fisher rats, produces cell kill at drug doses 1000 times lower than those necessary to cause the same mortality in the dark. The photocytocidal activity of this polycyclic quinone drag on neoplastic cells is superior to that of antitumor anthraquinone drugs, such as daunomycin and mitoxanthrone, and to the photosensitized antiviral activity previously reported for hypericin.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
