This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC(50) values against HIV-1 in the range of 0.04-0.15 μM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude.
New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity / D'Atri, Valentina; Oliviero, Giorgia; Amato, Jussara; Borbone, Nicola; D'Errico, Stefano; Mayol, Luciano; Piccialli, Vincenzo; Shozeb, Haider; Bart, Hoorelbeke; Jan, Balzarini; Piccialli, Gennaro. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 48:76(2012), pp. 9516-9518. [10.1039/c2cc34399a]
New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity
D'ATRI, VALENTINA;OLIVIERO, GIORGIA;AMATO, JUSSARA;BORBONE, NICOLA;D'ERRICO, STEFANO;MAYOL, LUCIANO;PICCIALLI, VINCENZO;PICCIALLI, GENNARO
2012
Abstract
This communication reports on the synthesis and biophysical, biological and SAR studies of a small library of new anti-HIV aptamers based on the tetra-end-linked G-quadruplex structure. The new aptamers showed EC(50) values against HIV-1 in the range of 0.04-0.15 μM as well as affinities for the HIV-1 gp120 envelope in the same order of magnitude.| File | Dimensione | Formato | |
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