Weinvestigatedtherelationshipofmetabolicsyndrome(MetS)anditsindividualcomponentswithincidenceofmildcognitiveimpairment (MCI) anditsprogressiontodementiainalargelongitudinalItalianpopulation-basedsamplewitha3.5-yearfollow-up.Atotalof2097 participants fromasampleof563265–84-year-oldsubjectsfromtheItalianLongitudinalStudyonAgingwereevaluated.MetSwasdefined according totheThirdAdultsTreatmentPaneloftheNationalCholesterolEducationProgramcriteria.MCI,dementia,Alzheimer’sdisease (AD), andvasculardementia(VaD)wereclassifiedusingcurrentpublishedcriteria.AmongMCIpatientsthosewithMetS(N = 49)hada higher riskofprogressiontodementia(HR,4.40;95%CI,1.30–14.82)comparedwiththosewithoutMetS(N = 72).Afteramultivariate adjustment, theriskinMCIpatientswithMetSapproximatelydoubled(multivariateadjustedHR,7.80,95%CI1.29–47.20)comparedwith those MCIwithoutMetS.Finally,amongnon-cognitivelyimpairedindividualstherewerenosignificantdifferencesinrisksofdeveloping MCI inthosewhowereaffectedbyMetS(N = 608)incomparisonwiththosewithoutMetS(N = 837),aswellasexcludingthoseindividuals with undernutritionorlowinflammatorystatuswithorwithoutundernutrition.Inourpopulation,amongMCIpatientsthepresenceofMetS independently predictedanincreasedriskofprogressiontodementiaover3.5yearsoffollow-up.
Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging / Solfrizzi, V; Scafato, E; Capurso, C; D'Introno, A; Colacicco, Am; Frisardi, V; Vendemiale, G; Baldereschi, M; Crepaldi, G; Di Carlo, A; Galluzzo, L; Gandin, C; Inzitari, D; Maggi, S; Capurso, A; Panza, F; Italian Longitudinal Study on Aging Working Group: Scafato, E; Galluzzo, L; Gandin, C; Capurso, A; Panza, F; Solfrizzi, V; Lepore, V; Livrea, P; Motta, L; Carnazzo, G; Motta, M; Bentivegna, P; Bonaiuto, S; Cruciani, G; Postacchini, D; Fermo, D; Inzitari, D; Amaducci, L; Dicarlo, A; Baldereschi, M; Gandolfo, C; Conti, M; Canal, N; Franceschi, M; Scarlato, G; Candelise, L; Scapini, E; Rengo, F; Abete, Pasquale; Cacciatore, F; Enzi, G; Battistin, L; Sergi, G; Crepaldi, G; Maggi, S; Minicucci, N; Noale, M; Grigoletto, G; Perissinotto, E; Carbonin, P.. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 32:(2011), pp. 1932-1941. [10.1016/j.neurobiolaging.2009.12.012]
Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging.
ABETE, PASQUALE;Cacciatore F;
2011
Abstract
Weinvestigatedtherelationshipofmetabolicsyndrome(MetS)anditsindividualcomponentswithincidenceofmildcognitiveimpairment (MCI) anditsprogressiontodementiainalargelongitudinalItalianpopulation-basedsamplewitha3.5-yearfollow-up.Atotalof2097 participants fromasampleof563265–84-year-oldsubjectsfromtheItalianLongitudinalStudyonAgingwereevaluated.MetSwasdefined according totheThirdAdultsTreatmentPaneloftheNationalCholesterolEducationProgramcriteria.MCI,dementia,Alzheimer’sdisease (AD), andvasculardementia(VaD)wereclassifiedusingcurrentpublishedcriteria.AmongMCIpatientsthosewithMetS(N = 49)hada higher riskofprogressiontodementia(HR,4.40;95%CI,1.30–14.82)comparedwiththosewithoutMetS(N = 72).Afteramultivariate adjustment, theriskinMCIpatientswithMetSapproximatelydoubled(multivariateadjustedHR,7.80,95%CI1.29–47.20)comparedwith those MCIwithoutMetS.Finally,amongnon-cognitivelyimpairedindividualstherewerenosignificantdifferencesinrisksofdeveloping MCI inthosewhowereaffectedbyMetS(N = 608)incomparisonwiththosewithoutMetS(N = 837),aswellasexcludingthoseindividuals with undernutritionorlowinflammatorystatuswithorwithoutundernutrition.Inourpopulation,amongMCIpatientsthepresenceofMetS independently predictedanincreasedriskofprogressiontodementiaover3.5yearsoffollow-up.| File | Dimensione | Formato | |
|---|---|---|---|
|
2011, Neurobiol Aging.pdf
non disponibili
Tipologia:
Versione Editoriale (PDF)
Licenza:
Accesso privato/ristretto
Dimensione
442.33 kB
Formato
Adobe PDF
|
442.33 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
