Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H(2)S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H(2)S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H(2)S donors hold promise as novel treatments for cardiovascular diseases
Thioglycine and l-thiovaline: biologically active H2S-donors / Zhou, Z; von Wantoch, Rm; Coletta, C; Szabo, C; Bucci, Mariarosaria; Cirino, Giuseppe; Topouzis, S; Papapetropoulos, A; Giannis, A.. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 1464-3391. - 20:8(2012), pp. 2675-2678. [10.1016/j.bmc.2012.02.028]
Thioglycine and l-thiovaline: biologically active H2S-donors.
BUCCI, MARIAROSARIA;CIRINO, GIUSEPPE;
2012
Abstract
Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H(2)S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H(2)S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H(2)S donors hold promise as novel treatments for cardiovascular diseases| File | Dimensione | Formato | |
|---|---|---|---|
|
bioorganic and Med Chem 2012.pdf
accesso aperto
Tipologia:
Documento in Post-print
Licenza:
Dominio pubblico
Dimensione
499.36 kB
Formato
Adobe PDF
|
499.36 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
