The presence of dimeric thyroglobulin (19S), after reduction and alkylation, suggests that within thyroglobulin there may be intermolecular cross-links, other than disulphide bridges. However, the nature of these intermolecular cross-links is still unknown. In this study, we show the presence of 3-3' dityrosine bridges in the molecule of bovine thyroglobulin by NMR and fluorescence studies. Also, we evaluated the role of iodination in dityrosine formation in vivo and in vitro.

Presence of dityrosine bridges in thyroglobulin and their relationship with iodination / Leonardi, Antonio; Acquaviva, R; Marinaccio, M; Liguoro, D; Fogolari, F; Di Jeso, B; Formisano, S; Consiglio, E.. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 202:1(1994), pp. 38-43. [10.1006/bbrc.1994.1890]

Presence of dityrosine bridges in thyroglobulin and their relationship with iodination.

LEONARDI, ANTONIO;
1994

Abstract

The presence of dimeric thyroglobulin (19S), after reduction and alkylation, suggests that within thyroglobulin there may be intermolecular cross-links, other than disulphide bridges. However, the nature of these intermolecular cross-links is still unknown. In this study, we show the presence of 3-3' dityrosine bridges in the molecule of bovine thyroglobulin by NMR and fluorescence studies. Also, we evaluated the role of iodination in dityrosine formation in vivo and in vitro.
1994
Presence of dityrosine bridges in thyroglobulin and their relationship with iodination / Leonardi, Antonio; Acquaviva, R; Marinaccio, M; Liguoro, D; Fogolari, F; Di Jeso, B; Formisano, S; Consiglio, E.. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 202:1(1994), pp. 38-43. [10.1006/bbrc.1994.1890]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/513005
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