The binding properties of AziRu, a ruthenium(III) complex with high antiproliferative activity, toward a hen egg white lysozyme have been investigated by X-ray crystallography and Raman microscopy. The data provide clear evidence on the mechanism of AziRu–protein adduct formation and of ligand exchange in the crystal state.
Interaction of Anticancer Ruthenium Compounds with Proteins: High-Resolution X-ray Structures and Raman Microscopy Studies of the Adduct between Hen Egg White Lysozyme and AziRu / Vergara, Alessandro; D'Errico, Gerardino; Montesarchio, Daniela; Mangiapia, Gaetano; Paduano, Luigi; Merlino, Antonello. - In: INORGANIC CHEMISTRY. - ISSN 1520-510X. - 52:8(2013), pp. 4157-4159. [10.1021/ic4004142]
Interaction of Anticancer Ruthenium Compounds with Proteins: High-Resolution X-ray Structures and Raman Microscopy Studies of the Adduct between Hen Egg White Lysozyme and AziRu
VERGARA, ALESSANDRO;D'ERRICO, GERARDINO;MONTESARCHIO, DANIELA;MANGIAPIA, GAETANO;PADUANO, LUIGI;MERLINO, ANTONELLO
2013
Abstract
The binding properties of AziRu, a ruthenium(III) complex with high antiproliferative activity, toward a hen egg white lysozyme have been investigated by X-ray crystallography and Raman microscopy. The data provide clear evidence on the mechanism of AziRu–protein adduct formation and of ligand exchange in the crystal state.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
