The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme / Biava, M., Battilocchio, C., Poce, G., Alfonso, S., Consalvi, S., Porretta, G.c., Schenone, S., Calderone, V., Martelli, A., Testai, L., Ghelardini, C., Di Cesare Mannelli, L., Sautebin, L., Rossi, A., Giordani, A., Patrignani, P., Anzini, M.. - In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0223-5234. - 58:(2012), pp. 287-298. [10.1016/j.ejmech.2012.10.014]
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme
SAUTEBIN, LIDIA;ROSSI, ANTONIETTA;
2012
Abstract
The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported. These molecules display enhanced nitric oxide releasing properties due to the presence of an ionisable moiety. The in vivo analgesic/anti-inflammatory activity was maintained in relation to the parent compounds.| File | Dimensione | Formato | |
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