We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules. © 2013 Elsevier Ltd. All rights reserved.
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity / Battilocchio, C; Poce, G; Alfonso, S; Porretta, Gc; Consalvi, S; Sautebin, Lidia; Pace, Simona; Rossi, Antonietta; Ghelardini, C; Di Cesare Mannelli, L; Schenone, S; Giordani, A; Di Francesco, L; Patrignani, P; Biava, M.. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 21:13(2013), pp. 3695-3701. [10.1016/j.bmc.2013.04.031]
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity
SAUTEBIN, LIDIA;PACE, SIMONA;ROSSI, ANTONIETTA;
2013
Abstract
We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules. © 2013 Elsevier Ltd. All rights reserved.| File | Dimensione | Formato | |
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