A novel pyrroloindole terpenoid, named fischerindoline (1), was isolated together with the known metabolites eurochevalierine, pyripyropenes A and E, sequiterpene, gliotoxin, and bis(dethio)bis(methylthio)gliotoxin from solid and liquid cultures of Neosartorya pseudofischeri. Fischerindoline was characterized as 3a-hydroxy-8-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole-2- carboxylic acid, 2-acetoxy-8a-hydroxy-5-isopropenyl-3,8-dimethyl-1,2,4a,5,6,7,8, 8a-octahydronaphthalen-1-yl ester by spectroscopic and chemical methods. Fischerindoline displays in vitro growth inhibitory activity in six human and mouse cancer cell lines.
Fischerindoline, a pyrroloindole sesquiterpenoid isolated from Neosartorya pseudofischeri, with in vitro growth inhibitory activity in human cancer cell lines / Masi, Marco; Andolfi, Anna; V., Mathieu; A., Boari; Cimmino, Alessio; L. Moreno Y., Banuls; M., Vurro; A., Kornienko; R., Kiss; Evidente, Antonio. - In: TETRAHEDRON. - ISSN 0040-4020. - 69:35(2013), pp. 7466-7470. [10.1016/j.tet.2013.06.031]
Fischerindoline, a pyrroloindole sesquiterpenoid isolated from Neosartorya pseudofischeri, with in vitro growth inhibitory activity in human cancer cell lines
MASI, MARCO;ANDOLFI, ANNA;CIMMINO, ALESSIO;EVIDENTE, ANTONIO
2013
Abstract
A novel pyrroloindole terpenoid, named fischerindoline (1), was isolated together with the known metabolites eurochevalierine, pyripyropenes A and E, sequiterpene, gliotoxin, and bis(dethio)bis(methylthio)gliotoxin from solid and liquid cultures of Neosartorya pseudofischeri. Fischerindoline was characterized as 3a-hydroxy-8-methyl-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole-2- carboxylic acid, 2-acetoxy-8a-hydroxy-5-isopropenyl-3,8-dimethyl-1,2,4a,5,6,7,8, 8a-octahydronaphthalen-1-yl ester by spectroscopic and chemical methods. Fischerindoline displays in vitro growth inhibitory activity in six human and mouse cancer cell lines.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
