BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation,
suicide attempts, and completed suicide in Huntington's disease (HD) compared
with the general population. This study investigates correlates and predictors of
suicidal ideation in HD.
METHODS: The study cohort consisted of 2106 HD mutation carriers, all
participating in the REGISTRY study of the European Huntington's Disease Network.
Of the 1937 participants without suicidal ideation at baseline, 945 had one or
more follow-up measurements. Participants were assessed for suicidal ideation by
the behavioural subscale of the Unified Huntington's Disease Rating Scale
(UHDRS). Correlates of suicidal ideation were analyzed using logistic regression
analysis and predictors were analyzed using Cox regression analysis.
RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation.
Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0),
anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a
previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood
(OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at
baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%.
Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI:
1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were
independent predictors of incident suicidal ideation, whereas a previous suicide
attempt was not predictive.
LIMITATIONS: As suicidal ideation was assessed by only one item, and participants
were a selection of all HD mutation carriers, the prevalence of suicidal ideation
was likely underestimated.
CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal
ideation is a priority in mutation carriers with a depressed mood and in those
using benzodiazepines.
Suicidal ideation in a European Huntington's disease population / Hubers, Aa; van Duijn, E; Roos, Ra; Craufurd, D; Rickards, H; Bernhard Landwehrmeyer, G; van der Mast, Rc; Giltay, Ej; CollaboratorsBachoud Lévi AC, REGISTRY investigators of the European Huntington's Disease N. e. t. w. o. r. k.; Bentivoglio, Ar; Biunno, I; Bonelli, Rm; Burgunder, Jm; Dunnett, Sb; Ferreira, Jj; Handley, Oj; Heiberg, A; Llmann, Ti; Landwehrmeyer, Gb; Levey, J; Ramos Arroyo, Ma; Nielsen, Je; Prokoivisto, S; Päivärinta, M; Roos, Ra; Rojo Sebastián, A; Tabrizi, Sj; Vandenberghe, W; Verellen Dumoulin, C; Zaremba, J; Uhrova, T; Wahlström, J; Barth, K; Correia Guedes, L; Finisterra, Am; Garde, Mb; Bos, R; Betz, S; Callaghan, J; Fullam, R; Ecker, D; Nielsen, Mg; Handley, Oj; Hvalstedt, C; Held, C; Koppers, K; Laurà, M; Horta, Sm; Descals, Am; Mestre, T; Minster, S; Monza, D; Mütze, L; Oehmen, M; Townhill, J; Orth, M; Padieu, H; Paterski, L; Peppa, N; Pro Koivisto, S; Roedig, V; Rialland, A; Røren, N; ??a??inková, P; Seliverstov, Y; Cubillo, Pt; Walsem, Mr; Wright, A; da Silva, Wv; Witjes Ané, Mn; Yudina, E; Zielonka, D; Zielonka, E; Zinzi, P; Bonelli, Rm; Herranhof, B; Holl, A; Kapfhammer, Hp; Koppitz, M; Magnet, M; Otti, D; Painold, A; Reisinger, K; Scheibl, M; Hecht, K; Lilek, S; Müller, N; Schöggl, H; Ullah, J; Brugger, F; Hepperger, C; Hotter, A; Seppi, K; Wenning, G; Buratti, L; Hametner, Em; Holas, C; Hametner, Em; Hussl, A; Poewe, W; Braunwarth, Em; Sprenger, F; Müller, C; Lilek, S; Sinadinosa, D; Walleczek, Am; Bonelli, Rm; Ladurner, G; Staffen, W; Flamez, A; Morez, V; de Raedt, S; Boogaerts, A; Vandenberghe, W; van Reijen, D; Klempí??, J; Majerová, V; Roth, J; Hartikainen, P; Hiivola, H; Martikainen, K; Tuuha, K; Ignatius, J; Kärppä, M; Åman, J; Mustonen, A; Kajula, O; Santala, M; Allain, P; Guérid, Ma; Gohier, B; Olivier, A; Prundean, A; Scherer Gagou, C; Verny, C; Bost, M; Babiloni, B; Debruxelles, S; Duché, C; Goizet, C; Lafoucrière, D; Jameau, L; Spampinato, U; De Bruycker, C; Cabaret, M; Carette, As; Defebvre, L; Decorte, E; Delval, A; Delliaux, M; Destee, A; Dujardin, K; Peter, M; Plomhouse, L; Sablonnière, B; Simonin, C; Defebvre, L; Lemaire, Mh; Manouvrier, S; Thibault Tanchou, S; Vuillaume, I; Krystkowiak, P; Duru, C; Roussel, M; Wannepain, S; Berrissoul, H; Bellonet, M; Courtin, F; Mantaux, B; Fasquel, V; Godefroy, O; Azulay, Jp; Fluchère, F; Delfini, M; Eusebio, A; Mundler, L; Longato, N; Rudolf, G; Steinmetz, G; Tranchant, C; Wagner, C; Zimmermann, M; Marcel, C; Calvas, F; Pariente, J; Démonet, Jf; Cheriet, S; Kosinski, Cm; Milkereit, E; Probst, D; Reetz, K; Sass, C; Schiefer, J; Schlangen, C; Werner, Cj; Gelderblom, H; Priller, J; Prüß, H; Spruth, Ej; Andrich, J; Ellrichmann, G; Hoffmann, R; Kaminski, B; Saft, C; Stamm, C; Lange, H; Bosredon, C; Maass, A; Schmidt, S; Storch, A; Wolz, M; Kohl, Z; Winkler, J; Capetian, P; Lambeck, J; Zucker, B; Boelmans, K; Ganos, C; Goerendt, I; Hidding, U; Lewerenz, J; Münchau, A; Orth, M; Schmalfeld, J; Stubbe, L; Zittel, S; Diercks, G; Dressler, D; Gorzolla, H; Schrader, C; Tacik, P; Heinicke, W; Longinus, B; Bürk, K; Möller, Jc; Rissling, I; Mühlau, M; Peinemann, A; Städtler, M; Weindl, A; Winkelmann, J; Ziegler, C; Bohlen, S; Hölzner, E; Lange, H; Reilmann, R; Sass, C; Dose, M; Leythaeuser, G; Marquard, R; Raab, T; Schrenk, C; Schuierer, M; Barth, K; Buck, A; Connemann, J; Ecker, D; Eschenbach, C; Held, C; Landwehrmeyer, B; Lezius, F; Nepper, S; Niess, A; Orth, M; Schwenk, D; Süßmuth, S; Trautmann, S; Weydt, P; Cormio, C; Sciruicchio, V; Serpino, C; Tommaso, M; Capellari, S; Cortelli, P; Gallassi, R; Poda, R; Rizzo, G; Scaglione, C; Bertini, E; Ghelli, E; Ginestroni, A; Massaro, F; Mechi, C; Paganini, M; Piacentini, S; Pradella, S; Romoli, Am; Sorbi, S; Abbruzzese, G; di Poggio, Mb; Di Maria, E; Ferrandes, G; Mandich, P; Marchese, R; Albanese, A; Di Bella, D; Di Donato, S; Gellera, C; Genitrini, S; Mariotti, C; Monza, D; Nanetti, L; Paridi, D; Soliveri, P; Tomasello, C; DE MICHELE, Giuseppe; Di Maio, L; Salvatore, Elena; Rinaldi, Carlo; Rossi, F; Massarelli, Marco; Roca, Alessandro; Ammendola, S; Russo, Cinzia; Squitieri, F; Elifani, F; Maglione, V; Di Pardo, A; Alberti, S; Griguoli, A; Amico, E; Martino, T; Petrollini, M; Bentivoglio, Ar; Catalli, C; Di Giacopo, R; Fasano, A; Frontali, M; Guidubaldi, A; Ialongo, T; Jacopini, G; Loria, G; Piano, C; Chiara, P; Quaranta, D; Romano, S; Soleti, F; Spadaro, M; Zinzi, P; Rinaldi, C; Rossi, F; Massarelli, M; Roca, A; Ammendola, S; Russo, Cv; Squitieri, F; Elifani, F; Maglione, V; Alberti, S; Griguoli, A; Amico, E; Martino, T; Petrollini, M; Bentivoglio, Ar; Catalli, C; Di Giacopo, R; Fasano, A; Frontali, M; Guidubaldi, A; Ialongo, T; Jacopini, G; Loria, G; Piano, C; Chiara, P; Quaranta, D; Romano, S; Soleti, F; Spadaro, M; Zinzi, P; van Hout, Ms; van Vugt, Jp; Weert, A; Bolwijn, J; Dekker, M; Leenders, K; Kremer, Hp; Bos, R; Dumas, Em; van den Bogaard, Sj; Roos, Ra; 't Hart, Ep; van Duijn, E; Økland, E; Hauge, E; Tyvoll, H; Heiberg, A; Walsem, Mr; Frich, J; Aaserud, O; Wehus, R; Bjørgo, K; Fannemel, M; Gørvell, P; Lorentzen, E; Koivisto, Sp; Retterstøl, L; Overland, T; Stokke, B; Sando, B; Dziadkiewicz, A; Nowak, M; Robowski, P; Sitek, E; Slawek, J; Soltan, W; Szinwelski, M; Blaszcyk, M; Boczarska Jedynak, M; Ciach Wysocka, E; Gorzkowska, A; Jasinska Myga, B; Opala, G; K??odowska Duda, G; Stompel, D; Banaszkiewicz, K; Bo??wi??ska, D; Szczudlik, A; Rudzi??ska, M; Wójcik, M; Dec, M; Krawczyk, M; Jaremek, Kb; Szczygie??, E; Stenwak, A; Ielewska, Aw; Bryl, A; Ciesielska, A; Klimberg, A; Marcinkowski, J; Sempo??owicz, J; Zielonka, D; Samara, H; Wi??niewski, B; Janik, P; Gogol, A; Kwiecinski, H; Jamrozik, Z; Kaminska, A; Antczak, J; Jachinska, K; Rakowicz, M; Richter, P; Rola, R; Ryglewicz, D; Sienkiewicz Jarosz, H; St??pniak, I; Witkowski, G; Zdzienicka, E; Zaremba, J; Su??ek, A; Krysa, W; St??pniak, I; Zieora Jakutowicz, K; Júlio, F; Januário, C; Mestre, T; Correia Guedes, L; Coelho, M; Mendes, T; Valadas, A; Ferreira, Jj; Timóteo, Â; Costa, C; Cavaco, S; Damásio, J; Loureiro, R; Magalhães, M; Andrade, C; Gago, M; Garrett, C; Guerra, Mr; Lima, J; Massano, J; Meireles, J; Herrera, Cd; Garcia, Pm; Barrero, F; Morales, B; Cubo, E; Mariscal, N; Sánchez, J; Alonso Frech, F; Perez, Mr; Fenollar, M; García, Rg; Quiroga, Pp; Rivera, Sv; Villanueva, C; Alegre, J; Bascuñana, M; Caldentey, Jg; Ventura, Mf; Ribas, Gg; Yébenes, Jg; López Sendón Moreno, Jl; Cubillo, Pt; García Ruíz, Pj; Martínez Descals, A; Artiga, Mj; Sánchez, V; Guerrero, R; Bárcenas, Ah; Noguera Perea, Mf; Fortuna, L; Martirio, M; Torres, A; Reinante, G; Moreau, Lv; Barbera, Ma; Guia, Db; Hernanz, Lc; Catena, Jl; Sebastián, Ar; Ferrer, Pq; Carruesco, Gt; Bas, J; Busquets, N; Calopa, M; Elorza, Md; Díez AjaLópez, C; Terol, Sd; Robert, Mf; Ruíz, Bg; Casado, Ag; Martínez, Ih; Viladrich, Cm; Càrdenas, Rp; Roca, E; Llesoy, Jr; Idiago, Jm; Vergara, Mr; García, Ss; Riballo, Av; González, Sg; Guisasola, Lm; Salvador, C; San Martín, Es; González, M; Gorospe, A; Legarda, I; Arques, Pn; Torres Rodríguez, Mj; Vives, B; Gaston, I; Ramos Arroyo, Ma; Martinez Jaurrieta, Md; Manuel, J; Moreno, G; Peña, Jc; Avarvarei, Ld; Bastida, Am; Recio, Mf; Vergé, Lr; Sánchez, Vs; Carrillo, F; Cáceres, Mt; Mir, P; Suarez, Mj; Bosca, M; Burguera, Ja; Garcia, Ac; Brugada, Fc; Martínez, Lm; Val, Jl; Loutfi, G; Olofsson, C; Stattin, El; Westman, L; Wikström, B; Lhagen, Se; Paucar, M; Svenningsson, P; Reza Soltani, Tw; Höglund, A; Sandström, B; Wahlström, J; Høsterey Ugander, U; Fredlund, G; Constantinescu, R; Neleborn Lingefjärd, L; Tedr off, J; Esmaeilzadeh, M; Winnberg, E; Pålhagen, S; Svennigsson, P; Paucar, M; Riza Soltani, Tw; Sundblom, J; Johansson, A; Wiklund, L; Ekwall, C; Göller, Ml; Petersén, A; Reimer, J; Widner, H; Burgunder, Jm; Stebler, Y; Kaelin, A; Romero, I; Schüpbach, M; Weber, S; Miedzybrodzka, Z; Rae, D; Downie, L; Simpson, S; Summers, F; Ure, A; Jack, R; Matheson, K; Akhtar, S; Crooks, J; Curtis, A; Souza, J; Rickards, H; Wright, J; Hayward, B; Sieradzan, K; Wright, A; Barker, Ra; O'Keefe, D; Di Pietro, A; Fisher, K; Hill, S; Mason, S; Swain, R; Valle, N; Guzman, ; Bisson, J; Busse, M; Butcher, C; Callaghan, J; Clenaghan, C; Dunnett, S; Fullam, R; Handley, O; Hunt, S; Hughes, A; Johnstone, C; Jones, L; Jones, U; Khalil, H; Minster, S; Owen, M; Price, K; Rose, Le; Townhill, J; Rosser, A; Porteous, M; Edwards, M; Ho, C; Mcgill, M; Pearson, P; Brockie, P; Foster, J; Johns, N; Mckenzie, S; Rothery, J; Thomas, G; Yates, S; Miller, J; Ritchie, S; Burrows, L; Fletcher, A; Harding, A; Laver, F; Silva, M; Thomson, A; Rowett, L; Gallantrae, D; Longthorpe, M; Markova, I; Raman, A; Hamer, S; Wild, S; Yarduiman, P; Chu, C; Kraus, A; Wild, S; Yardumian, P; Musgrave, H; Rowett, L; Toscano, J; Jamieson, S; Hobson, E; Clayton, C; Dipple, H; Middleton, J; Freire Patino, D; Andrews, T; Dougherty, A; Kavalier, F; Golding, C; Laing, H; Lashwood, A; Robertson, D; Ruddy, D; Whaite, A; Santhouse, A; Patton, M; Peterson, M; Rose, S; Andrews, T; Bruno, S; Chu, E; Doherty, K; Golding, C; Haider, S; Hensman, D; Lahiri, N; Lewis, M; Novak, M; Patel, A; Robertson, N; Rosser, E; Tabrizi, S; Taylor, R; Warner, T; Wild, E; Craufurd, D; Fullam, R; Howard, L; Sollom, A; Snowden, J; Thompson, J; Callaghan, J; Jones, M; Murphy, H; Trender Gerhard, I; Rogers, D; Bek, J; Oughton, E; Johnson, L; Hare, M; Arran, N; Verstraelen, N; Partington Jones, L; Huson, S; Stopford, C; Westmoreland, L; Davidson, J; Morgan, K; Savage, L; Singh, B; Komati, S; Nemeth, Ah; Armstrong, R; Valentine, R; Siuda, G; Harrison, D; Hughes, M; Parkinson, A; Soltysiak, B; Burn, J; Coleman, C; Bandmann, O; Bradbury, A; Gill, P; Fairtlough, H; Fillingham, K; Foustanos, I; Kazoka, M; O'Donovan, K; Peppa, N; Taylor, C; Tidswell, K; Quarrell, O.. - In: JOURNAL OF AFFECTIVE DISORDERS. - ISSN 0165-0327. - (2013), pp. 248-258. [10.1016/j.jad.2013.06.001]
Suicidal ideation in a European Huntington's disease population.
Hubers AA; van Duijn E; Roos RA; Craufurd D; Rickards H; Bernhard Landwehrmeyer G; van der Mast RC; Giltay EJ; REGISTRY investigators of the European Huntington's Disease N.e.t.w.o.r.k. CollaboratorsBachoud Lévi AC; Bentivoglio AR; Biunno I; Bonelli RM; Burgunder JM; Dunnett SB; Ferreira JJ; Handley OJ; Heiberg A; llmann TI; Landwehrmeyer GB; Levey J; Ramos Arroyo MA; Nielsen JE; ProKoivisto S; Päivärinta M; Roos RA; Rojo Sebastián A; Tabrizi SJ; Vandenberghe W; Verellen Dumoulin C; Zaremba J; Uhrova T; Wahlström J; Barth K; Correia Guedes L; Finisterra AM; Garde MB; Bos R; Betz S; Callaghan J; Fullam R; Ecker D; Nielsen MG; Handley OJ; Hvalstedt C; Held C; Koppers K; Laurà M; Horta SM; Descals AM; Mestre T; Minster S; Monza D; Mütze L; Oehmen M; Townhill J; Orth M; Padieu H; Paterski L; Peppa N; Pro Koivisto S; Roedig V; Rialland A; Røren N; ??a??inková P; Seliverstov Y; Cubillo PT; Walsem MR; Wright A; da Silva WV; Witjes Ané MN; Yudina E; Zielonka D; Zielonka E; Zinzi P; Bonelli RM; Herranhof B; Holl A; Kapfhammer HP; Koppitz M; Magnet M; Otti D; Painold A; Reisinger K; Scheibl M; Hecht K; Lilek S; Müller N; Schöggl H; Ullah J; Brugger F; Hepperger C; Hotter A; Seppi K; Wenning G; Buratti L; Hametner EM; Holas C; Hametner EM; Hussl A; Poewe W; Braunwarth EM; Sprenger F; Müller C; Lilek S; Sinadinosa D; Walleczek AM; Bonelli RM; Ladurner G; Staffen W; Flamez A; Morez V; de Raedt S; Boogaerts A; Vandenberghe W; van Reijen D; Klempí?? J; Majerová V; Roth J; Hartikainen P; Hiivola H; Martikainen K; Tuuha K; Ignatius J; Kärppä M; Åman J; Mustonen A; Kajula O; Santala M; Allain P; Guérid MA; Gohier B; Olivier A; Prundean A; Scherer Gagou C; Verny C; Bost M; Babiloni B; Debruxelles S; Duché C; Goizet C; Lafoucrière D; Jameau L; Spampinato U; De Bruycker C; Cabaret M; Carette AS; Defebvre L; Decorte E; Delval A; Delliaux M; Destee A; Dujardin K; Peter M; Plomhouse L; Sablonnière B; Simonin C; Defebvre L; Lemaire MH; Manouvrier S; Thibault Tanchou S; Vuillaume I; Krystkowiak P; Duru C; Roussel M; Wannepain S; Berrissoul H; Bellonet M; Courtin F; Mantaux B; Fasquel V; Godefroy O; Azulay JP; Fluchère F; Delfini M; Eusebio A; Mundler L; Longato N; Rudolf G; Steinmetz G; Tranchant C; Wagner C; Zimmermann M; Marcel C; Calvas F; Pariente J; Démonet JF; Cheriet S; Kosinski CM; Milkereit E; Probst D; Reetz K; Sass C; Schiefer J; Schlangen C; Werner CJ; Gelderblom H; Priller J; Prüß H; Spruth EJ; Andrich J; Ellrichmann G; Hoffmann R; Kaminski B; Saft C; Stamm C; Lange H; Bosredon C; Maass A; Schmidt S; Storch A; Wolz M; Kohl Z; Winkler J; Capetian P; Lambeck J; Zucker B; Boelmans K; Ganos C; Goerendt I; Hidding U; Lewerenz J; Münchau A; Orth M; Schmalfeld J; Stubbe L; Zittel S; Diercks G; Dressler D; Gorzolla H; Schrader C; Tacik P; Heinicke W; Longinus B; Bürk K; Möller JC; Rissling I; Mühlau M; Peinemann A; Städtler M; Weindl A; Winkelmann J; Ziegler C; Bohlen S; Hölzner E; Lange H; Reilmann R; Sass C; Dose M; Leythaeuser G; Marquard R; Raab T; Schrenk C; Schuierer M; Barth K; Buck A; Connemann J; Ecker D; Eschenbach C; Held C; Landwehrmeyer B; Lezius F; Nepper S; Niess A; Orth M; Schwenk D; Süßmuth S; Trautmann S; Weydt P; Cormio C; Sciruicchio V; Serpino C; Tommaso M; Capellari S; Cortelli P; Gallassi R; Poda R; Rizzo G; Scaglione C; Bertini E; Ghelli E; Ginestroni A; Massaro F; Mechi C; Paganini M; Piacentini S; Pradella S; Romoli AM; Sorbi S; Abbruzzese G; di Poggio MB; Di Maria E; Ferrandes G; Mandich P; Marchese R; Albanese A; Di Bella D; Di Donato S; Gellera C; Genitrini S; Mariotti C; Monza D; Nanetti L; Paridi D; Soliveri P; Tomasello C; DE MICHELE, GIUSEPPE ;Di Maio L; SALVATORE, ELENA ;RINALDI, CARLO ;Rossi F; MASSARELLI, MARCO ;ROCA, ALESSANDRO ;Ammendola S; RUSSO, CINZIA ;Squitieri F; Elifani F; Maglione V; Di Pardo A; Alberti S; Griguoli A; Amico E; Martino T; Petrollini M; Bentivoglio AR; Catalli C; Di Giacopo R; Fasano A; Frontali M; Guidubaldi A; Ialongo T; Jacopini G; Loria G; Piano C; Chiara P; Quaranta D; Romano S; Soleti F; Spadaro M; Zinzi P; Rinaldi C; Rossi F; Massarelli M; Roca A; Ammendola S; Russo CV ;Squitieri F; Elifani F; Maglione V; Alberti S; Griguoli A; Amico E; Martino T; Petrollini M; Bentivoglio AR; Catalli C; Di Giacopo R; Fasano A; Frontali M; Guidubaldi A; Ialongo T; Jacopini G; Loria G; Piano C; Chiara P; Quaranta D; Romano S; Soleti F; Spadaro M; Zinzi P; van Hout MS; van Vugt JP; Weert A; Bolwijn J; Dekker M; Leenders K; Kremer HP; Bos R; Dumas EM; van den Bogaard SJ; Roos RA; 't Hart EP; van Duijn E; Økland E; Hauge E; Tyvoll H; Heiberg A; Walsem MR; Frich J; Aaserud O; Wehus R; Bjørgo K; Fannemel M; Gørvell P; Lorentzen E; Koivisto SP; Retterstøl L; Overland T; Stokke B; Sando B; Dziadkiewicz A; Nowak M; Robowski P; Sitek E; Slawek J; Soltan W; Szinwelski M; Blaszcyk M; Boczarska Jedynak M; Ciach Wysocka E; Gorzkowska A; Jasinska Myga B; Opala G; K??odowska Duda G; Stompel D; Banaszkiewicz K; Bo??wi??ska D; Szczudlik A; Rudzi??ska M; Wójcik M; Dec M; Krawczyk M; Jaremek KB; Szczygie?? E; Stenwak A; ielewska AW; Bryl A; Ciesielska A; Klimberg A; Marcinkowski J; Sempo??owicz J; Zielonka D; Samara H; Wi??niewski B; Janik P; Gogol A; Kwiecinski H; Jamrozik Z; Kaminska A; Antczak J; Jachinska K; Rakowicz M; Richter P; Rola R; Ryglewicz D; Sienkiewicz Jarosz H; St??pniak I; Witkowski G; Zdzienicka E; Zaremba J; Su??ek A; Krysa W; St??pniak I; Zieora Jakutowicz K; Júlio F; Januário C; Mestre T; Correia Guedes L; Coelho M; Mendes T; Valadas A; Ferreira JJ; Timóteo Â; Costa C; Cavaco S; Damásio J; Loureiro R; Magalhães M; Andrade C; Gago M; Garrett C; Guerra MR; Lima J; Massano J; Meireles J; Herrera CD; Garcia PM; Barrero F; Morales B; Cubo E; Mariscal N; Sánchez J; Alonso Frech F; Perez MR; Fenollar M; García RG; Quiroga PP; Rivera SV; Villanueva C; Alegre J; Bascuñana M; Caldentey JG; Ventura MF; Ribas GG; Yébenes JG; López Sendón Moreno JL; Cubillo PT; García Ruíz PJ; Martínez Descals A; Artiga MJ; Sánchez V; Guerrero R; Bárcenas AH; Noguera Perea MF; Fortuna L; Martirio M; Torres A; Reinante G; Moreau LV; Barbera MA; Guia DB; Hernanz LC; Catena JL; Sebastián AR; Ferrer PQ; Carruesco GT; Bas J; Busquets N; Calopa M; Elorza MD; Díez AjaLópez C; Terol SD; Robert MF; Ruíz BG; Casado AG; Martínez IH; Viladrich CM; Càrdenas RP; Roca E; Llesoy JR; Idiago JM; Vergara MR; García SS; Riballo AV; González SG; Guisasola LM; Salvador C; San Martín ES; González M; Gorospe A; Legarda I; Arques PN; Torres Rodríguez MJ; Vives B; Gaston I; Ramos Arroyo MA; Martinez Jaurrieta MD; Manuel J; Moreno G; Peña JC; Avarvarei LD; Bastida AM; Recio MF; Vergé LR; Sánchez VS; Carrillo F; Cáceres MT; Mir P; Suarez MJ; Bosca M; Burguera JA; Garcia AC; Brugada FC; Martínez LM; Val JL; Loutfi G; Olofsson C; Stattin EL; Westman L; Wikström B; lhagen SE; Paucar M; Svenningsson P; Reza Soltani TW; Höglund A; Sandström B; Wahlström J; Høsterey Ugander U; Fredlund G; Constantinescu R; Neleborn Lingefjärd L; Tedr off J; Esmaeilzadeh M; Winnberg E; Pålhagen S; Svennigsson P; Paucar M; Riza Soltani TW; Sundblom J; Johansson A; Wiklund L; Ekwall C; Göller ML; Petersén A; Reimer J; Widner H; Burgunder JM; Stebler Y; Kaelin A; Romero I; Schüpbach M; Weber S; Miedzybrodzka Z; Rae D; Downie L; Simpson S; Summers F; Ure A; Jack R; Matheson K; Akhtar S; Crooks J; Curtis A; Souza J; Rickards H; Wright J; Hayward B; Sieradzan K; Wright A; Barker RA; O'Keefe D; Di Pietro A; Fisher K; Hill S; Mason S; Swain R; Valle N; Guzman; Bisson J; Busse M; Butcher C; Callaghan J; Clenaghan C; Dunnett S; Fullam R; Handley O; Hunt S; Hughes A; Johnstone C; Jones L; Jones U; Khalil H; Minster S; Owen M; Price K; Rose LE; Townhill J; Rosser A; Porteous M; Edwards M; Ho C; McGill M; Pearson P; Brockie P; Foster J; Johns N; McKenzie S; Rothery J; Thomas G; Yates S; Miller J; Ritchie S; Burrows L; Fletcher A; Harding A; Laver F; Silva M; Thomson A; Rowett L; Gallantrae D; Longthorpe M; Markova I; Raman A; Hamer S; Wild S; Yarduiman P; Chu C; Kraus A; Wild S; Yardumian P; Musgrave H; Rowett L; Toscano J; Jamieson S; Hobson E; Clayton C; Dipple H; Middleton J; Freire Patino D; Andrews T; Dougherty A; Kavalier F; Golding C; Laing H; Lashwood A; Robertson D; Ruddy D; Whaite A; Santhouse A; Patton M; Peterson M; Rose S; Andrews T; Bruno S; Chu E; Doherty K; Golding C; Haider S; Hensman D; Lahiri N; Lewis M; Novak M; Patel A; Robertson N; Rosser E; Tabrizi S; Taylor R; Warner T; Wild E; Craufurd D; Fullam R; Howard L; Sollom A; Snowden J; Thompson J; Callaghan J; Jones M; Murphy H; Trender Gerhard I; Rogers D; Bek J; Oughton E; Johnson L; Hare M; Arran N; Verstraelen N; Partington Jones L; Huson S; Stopford C; Westmoreland L; Davidson J; Morgan K; Savage L; Singh B; Komati S; Nemeth AH; Armstrong R; Valentine R; Siuda G; Harrison D; Hughes M; Parkinson A; Soltysiak B; Burn J; Coleman C; Bandmann O; Bradbury A; Gill P; Fairtlough H; Fillingham K; Foustanos I; Kazoka M; O'Donovan K; Peppa N; Taylor C; Tidswell K; Quarrell O.
2013
Abstract
BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation,
suicide attempts, and completed suicide in Huntington's disease (HD) compared
with the general population. This study investigates correlates and predictors of
suicidal ideation in HD.
METHODS: The study cohort consisted of 2106 HD mutation carriers, all
participating in the REGISTRY study of the European Huntington's Disease Network.
Of the 1937 participants without suicidal ideation at baseline, 945 had one or
more follow-up measurements. Participants were assessed for suicidal ideation by
the behavioural subscale of the Unified Huntington's Disease Rating Scale
(UHDRS). Correlates of suicidal ideation were analyzed using logistic regression
analysis and predictors were analyzed using Cox regression analysis.
RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation.
Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0),
anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a
previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood
(OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at
baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%.
Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI:
1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were
independent predictors of incident suicidal ideation, whereas a previous suicide
attempt was not predictive.
LIMITATIONS: As suicidal ideation was assessed by only one item, and participants
were a selection of all HD mutation carriers, the prevalence of suicidal ideation
was likely underestimated.
CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal
ideation is a priority in mutation carriers with a depressed mood and in those
using benzodiazepines.
Citazione
Suicidal ideation in a European Huntington's disease population / Hubers, Aa; van Duijn, E; Roos, Ra; Craufurd, D; Rickards, H; Bernhard Landwehrmeyer, G; van der Mast, Rc; Giltay, Ej; CollaboratorsBachoud Lévi AC, REGISTRY investigators of the European Huntington's Disease N. e. t. w. o. r. k.; Bentivoglio, Ar; Biunno, I; Bonelli, Rm; Burgunder, Jm; Dunnett, Sb; Ferreira, Jj; Handley, Oj; Heiberg, A; Llmann, Ti; Landwehrmeyer, Gb; Levey, J; Ramos Arroyo, Ma; Nielsen, Je; Prokoivisto, S; Päivärinta, M; Roos, Ra; Rojo Sebastián, A; Tabrizi, Sj; Vandenberghe, W; Verellen Dumoulin, C; Zaremba, J; Uhrova, T; Wahlström, J; Barth, K; Correia Guedes, L; Finisterra, Am; Garde, Mb; Bos, R; Betz, S; Callaghan, J; Fullam, R; Ecker, D; Nielsen, Mg; Handley, Oj; Hvalstedt, C; Held, C; Koppers, K; Laurà, M; Horta, Sm; Descals, Am; Mestre, T; Minster, S; Monza, D; Mütze, L; Oehmen, M; Townhill, J; Orth, M; Padieu, H; Paterski, L; Peppa, N; Pro Koivisto, S; Roedig, V; Rialland, A; Røren, N; ??a??inková, P; Seliverstov, Y; Cubillo, Pt; Walsem, Mr; Wright, A; da Silva, Wv; Witjes Ané, Mn; Yudina, E; Zielonka, D; Zielonka, E; Zinzi, P; Bonelli, Rm; Herranhof, B; Holl, A; Kapfhammer, Hp; Koppitz, M; Magnet, M; Otti, D; Painold, A; Reisinger, K; Scheibl, M; Hecht, K; Lilek, S; Müller, N; Schöggl, H; Ullah, J; Brugger, F; Hepperger, C; Hotter, A; Seppi, K; Wenning, G; Buratti, L; Hametner, Em; Holas, C; Hametner, Em; Hussl, A; Poewe, W; Braunwarth, Em; Sprenger, F; Müller, C; Lilek, S; Sinadinosa, D; Walleczek, Am; Bonelli, Rm; Ladurner, G; Staffen, W; Flamez, A; Morez, V; de Raedt, S; Boogaerts, A; Vandenberghe, W; van Reijen, D; Klempí??, J; Majerová, V; Roth, J; Hartikainen, P; Hiivola, H; Martikainen, K; Tuuha, K; Ignatius, J; Kärppä, M; Åman, J; Mustonen, A; Kajula, O; Santala, M; Allain, P; Guérid, Ma; Gohier, B; Olivier, A; Prundean, A; Scherer Gagou, C; Verny, C; Bost, M; Babiloni, B; Debruxelles, S; Duché, C; Goizet, C; Lafoucrière, D; Jameau, L; Spampinato, U; De Bruycker, C; Cabaret, M; Carette, As; Defebvre, L; Decorte, E; Delval, A; Delliaux, M; Destee, A; Dujardin, K; Peter, M; Plomhouse, L; Sablonnière, B; Simonin, C; Defebvre, L; Lemaire, Mh; Manouvrier, S; Thibault Tanchou, S; Vuillaume, I; Krystkowiak, P; Duru, C; Roussel, M; Wannepain, S; Berrissoul, H; Bellonet, M; Courtin, F; Mantaux, B; Fasquel, V; Godefroy, O; Azulay, Jp; Fluchère, F; Delfini, M; Eusebio, A; Mundler, L; Longato, N; Rudolf, G; Steinmetz, G; Tranchant, C; Wagner, C; Zimmermann, M; Marcel, C; Calvas, F; Pariente, J; Démonet, Jf; Cheriet, S; Kosinski, Cm; Milkereit, E; Probst, D; Reetz, K; Sass, C; Schiefer, J; Schlangen, C; Werner, Cj; Gelderblom, H; Priller, J; Prüß, H; Spruth, Ej; Andrich, J; Ellrichmann, G; Hoffmann, R; Kaminski, B; Saft, C; Stamm, C; Lange, H; Bosredon, C; Maass, A; Schmidt, S; Storch, A; Wolz, M; Kohl, Z; Winkler, J; Capetian, P; Lambeck, J; Zucker, B; Boelmans, K; Ganos, C; Goerendt, I; Hidding, U; Lewerenz, J; Münchau, A; Orth, M; Schmalfeld, J; Stubbe, L; Zittel, S; Diercks, G; Dressler, D; Gorzolla, H; Schrader, C; Tacik, P; Heinicke, W; Longinus, B; Bürk, K; Möller, Jc; Rissling, I; Mühlau, M; Peinemann, A; Städtler, M; Weindl, A; Winkelmann, J; Ziegler, C; Bohlen, S; Hölzner, E; Lange, H; Reilmann, R; Sass, C; Dose, M; Leythaeuser, G; Marquard, R; Raab, T; Schrenk, C; Schuierer, M; Barth, K; Buck, A; Connemann, J; Ecker, D; Eschenbach, C; Held, C; Landwehrmeyer, B; Lezius, F; Nepper, S; Niess, A; Orth, M; Schwenk, D; Süßmuth, S; Trautmann, S; Weydt, P; Cormio, C; Sciruicchio, V; Serpino, C; Tommaso, M; Capellari, S; Cortelli, P; Gallassi, R; Poda, R; Rizzo, G; Scaglione, C; Bertini, E; Ghelli, E; Ginestroni, A; Massaro, F; Mechi, C; Paganini, M; Piacentini, S; Pradella, S; Romoli, Am; Sorbi, S; Abbruzzese, G; di Poggio, Mb; Di Maria, E; Ferrandes, G; Mandich, P; Marchese, R; Albanese, A; Di Bella, D; Di Donato, S; Gellera, C; Genitrini, S; Mariotti, C; Monza, D; Nanetti, L; Paridi, D; Soliveri, P; Tomasello, C; DE MICHELE, Giuseppe; Di Maio, L; Salvatore, Elena; Rinaldi, Carlo; Rossi, F; Massarelli, Marco; Roca, Alessandro; Ammendola, S; Russo, Cinzia; Squitieri, F; Elifani, F; Maglione, V; Di Pardo, A; Alberti, S; Griguoli, A; Amico, E; Martino, T; Petrollini, M; Bentivoglio, Ar; Catalli, C; Di Giacopo, R; Fasano, A; Frontali, M; Guidubaldi, A; Ialongo, T; Jacopini, G; Loria, G; Piano, C; Chiara, P; Quaranta, D; Romano, S; Soleti, F; Spadaro, M; Zinzi, P; Rinaldi, C; Rossi, F; Massarelli, M; Roca, A; Ammendola, S; Russo, Cv; Squitieri, F; Elifani, F; Maglione, V; Alberti, S; Griguoli, A; Amico, E; Martino, T; Petrollini, M; Bentivoglio, Ar; Catalli, C; Di Giacopo, R; Fasano, A; Frontali, M; Guidubaldi, A; Ialongo, T; Jacopini, G; Loria, G; Piano, C; Chiara, P; Quaranta, D; Romano, S; Soleti, F; Spadaro, M; Zinzi, P; van Hout, Ms; van Vugt, Jp; Weert, A; Bolwijn, J; Dekker, M; Leenders, K; Kremer, Hp; Bos, R; Dumas, Em; van den Bogaard, Sj; Roos, Ra; 't Hart, Ep; van Duijn, E; Økland, E; Hauge, E; Tyvoll, H; Heiberg, A; Walsem, Mr; Frich, J; Aaserud, O; Wehus, R; Bjørgo, K; Fannemel, M; Gørvell, P; Lorentzen, E; Koivisto, Sp; Retterstøl, L; Overland, T; Stokke, B; Sando, B; Dziadkiewicz, A; Nowak, M; Robowski, P; Sitek, E; Slawek, J; Soltan, W; Szinwelski, M; Blaszcyk, M; Boczarska Jedynak, M; Ciach Wysocka, E; Gorzkowska, A; Jasinska Myga, B; Opala, G; K??odowska Duda, G; Stompel, D; Banaszkiewicz, K; Bo??wi??ska, D; Szczudlik, A; Rudzi??ska, M; Wójcik, M; Dec, M; Krawczyk, M; Jaremek, Kb; Szczygie??, E; Stenwak, A; Ielewska, Aw; Bryl, A; Ciesielska, A; Klimberg, A; Marcinkowski, J; Sempo??owicz, J; Zielonka, D; Samara, H; Wi??niewski, B; Janik, P; Gogol, A; Kwiecinski, H; Jamrozik, Z; Kaminska, A; Antczak, J; Jachinska, K; Rakowicz, M; Richter, P; Rola, R; Ryglewicz, D; Sienkiewicz Jarosz, H; St??pniak, I; Witkowski, G; Zdzienicka, E; Zaremba, J; Su??ek, A; Krysa, W; St??pniak, I; Zieora Jakutowicz, K; Júlio, F; Januário, C; Mestre, T; Correia Guedes, L; Coelho, M; Mendes, T; Valadas, A; Ferreira, Jj; Timóteo, Â; Costa, C; Cavaco, S; Damásio, J; Loureiro, R; Magalhães, M; Andrade, C; Gago, M; Garrett, C; Guerra, Mr; Lima, J; Massano, J; Meireles, J; Herrera, Cd; Garcia, Pm; Barrero, F; Morales, B; Cubo, E; Mariscal, N; Sánchez, J; Alonso Frech, F; Perez, Mr; Fenollar, M; García, Rg; Quiroga, Pp; Rivera, Sv; Villanueva, C; Alegre, J; Bascuñana, M; Caldentey, Jg; Ventura, Mf; Ribas, Gg; Yébenes, Jg; López Sendón Moreno, Jl; Cubillo, Pt; García Ruíz, Pj; Martínez Descals, A; Artiga, Mj; Sánchez, V; Guerrero, R; Bárcenas, Ah; Noguera Perea, Mf; Fortuna, L; Martirio, M; Torres, A; Reinante, G; Moreau, Lv; Barbera, Ma; Guia, Db; Hernanz, Lc; Catena, Jl; Sebastián, Ar; Ferrer, Pq; Carruesco, Gt; Bas, J; Busquets, N; Calopa, M; Elorza, Md; Díez AjaLópez, C; Terol, Sd; Robert, Mf; Ruíz, Bg; Casado, Ag; Martínez, Ih; Viladrich, Cm; Càrdenas, Rp; Roca, E; Llesoy, Jr; Idiago, Jm; Vergara, Mr; García, Ss; Riballo, Av; González, Sg; Guisasola, Lm; Salvador, C; San Martín, Es; González, M; Gorospe, A; Legarda, I; Arques, Pn; Torres Rodríguez, Mj; Vives, B; Gaston, I; Ramos Arroyo, Ma; Martinez Jaurrieta, Md; Manuel, J; Moreno, G; Peña, Jc; Avarvarei, Ld; Bastida, Am; Recio, Mf; Vergé, Lr; Sánchez, Vs; Carrillo, F; Cáceres, Mt; Mir, P; Suarez, Mj; Bosca, M; Burguera, Ja; Garcia, Ac; Brugada, Fc; Martínez, Lm; Val, Jl; Loutfi, G; Olofsson, C; Stattin, El; Westman, L; Wikström, B; Lhagen, Se; Paucar, M; Svenningsson, P; Reza Soltani, Tw; Höglund, A; Sandström, B; Wahlström, J; Høsterey Ugander, U; Fredlund, G; Constantinescu, R; Neleborn Lingefjärd, L; Tedr off, J; Esmaeilzadeh, M; Winnberg, E; Pålhagen, S; Svennigsson, P; Paucar, M; Riza Soltani, Tw; Sundblom, J; Johansson, A; Wiklund, L; Ekwall, C; Göller, Ml; Petersén, A; Reimer, J; Widner, H; Burgunder, Jm; Stebler, Y; Kaelin, A; Romero, I; Schüpbach, M; Weber, S; Miedzybrodzka, Z; Rae, D; Downie, L; Simpson, S; Summers, F; Ure, A; Jack, R; Matheson, K; Akhtar, S; Crooks, J; Curtis, A; Souza, J; Rickards, H; Wright, J; Hayward, B; Sieradzan, K; Wright, A; Barker, Ra; O'Keefe, D; Di Pietro, A; Fisher, K; Hill, S; Mason, S; Swain, R; Valle, N; Guzman, ; Bisson, J; Busse, M; Butcher, C; Callaghan, J; Clenaghan, C; Dunnett, S; Fullam, R; Handley, O; Hunt, S; Hughes, A; Johnstone, C; Jones, L; Jones, U; Khalil, H; Minster, S; Owen, M; Price, K; Rose, Le; Townhill, J; Rosser, A; Porteous, M; Edwards, M; Ho, C; Mcgill, M; Pearson, P; Brockie, P; Foster, J; Johns, N; Mckenzie, S; Rothery, J; Thomas, G; Yates, S; Miller, J; Ritchie, S; Burrows, L; Fletcher, A; Harding, A; Laver, F; Silva, M; Thomson, A; Rowett, L; Gallantrae, D; Longthorpe, M; Markova, I; Raman, A; Hamer, S; Wild, S; Yarduiman, P; Chu, C; Kraus, A; Wild, S; Yardumian, P; Musgrave, H; Rowett, L; Toscano, J; Jamieson, S; Hobson, E; Clayton, C; Dipple, H; Middleton, J; Freire Patino, D; Andrews, T; Dougherty, A; Kavalier, F; Golding, C; Laing, H; Lashwood, A; Robertson, D; Ruddy, D; Whaite, A; Santhouse, A; Patton, M; Peterson, M; Rose, S; Andrews, T; Bruno, S; Chu, E; Doherty, K; Golding, C; Haider, S; Hensman, D; Lahiri, N; Lewis, M; Novak, M; Patel, A; Robertson, N; Rosser, E; Tabrizi, S; Taylor, R; Warner, T; Wild, E; Craufurd, D; Fullam, R; Howard, L; Sollom, A; Snowden, J; Thompson, J; Callaghan, J; Jones, M; Murphy, H; Trender Gerhard, I; Rogers, D; Bek, J; Oughton, E; Johnson, L; Hare, M; Arran, N; Verstraelen, N; Partington Jones, L; Huson, S; Stopford, C; Westmoreland, L; Davidson, J; Morgan, K; Savage, L; Singh, B; Komati, S; Nemeth, Ah; Armstrong, R; Valentine, R; Siuda, G; Harrison, D; Hughes, M; Parkinson, A; Soltysiak, B; Burn, J; Coleman, C; Bandmann, O; Bradbury, A; Gill, P; Fairtlough, H; Fillingham, K; Foustanos, I; Kazoka, M; O'Donovan, K; Peppa, N; Taylor, C; Tidswell, K; Quarrell, O.. - In: JOURNAL OF AFFECTIVE DISORDERS. - ISSN 0165-0327. - (2013), pp. 248-258. [10.1016/j.jad.2013.06.001]
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
Sei sicuro che questo prodotto debba essere cancellato?
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande. La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.