In this work we report a kinetic and thermodynamic study relative to the formation of gel systems based on PNA and PNA/DNA dendrimers, useful for drug delivery or diagnostic applications. We realized two kinds of systems: a PNA-based monomolecular system formed by an autoassembling PNA tridendron (A) and a PNA/DNA bimolecular system based on a PNA tridendron with a mixed sequence and a DNA crosslinker (B). Both systems have the ability to form a three-dimensional network by means of specific W-C base pairing.
Thermodynamic Studies on PNA and PNA/DNA Dendrimer Formation / Maria, Moccia; Musumeci, Domenica; Margherita, Valente; Giovanni N., Roviello; Roberto, Sapio; Pedone, Carlo; Enrico M., Bucci. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - 26:8-9(2007), pp. 1173-1176. [10.1080/15257770701527703]
Thermodynamic Studies on PNA and PNA/DNA Dendrimer Formation
MUSUMECI, DOMENICA;PEDONE, CARLO;
2007
Abstract
In this work we report a kinetic and thermodynamic study relative to the formation of gel systems based on PNA and PNA/DNA dendrimers, useful for drug delivery or diagnostic applications. We realized two kinds of systems: a PNA-based monomolecular system formed by an autoassembling PNA tridendron (A) and a PNA/DNA bimolecular system based on a PNA tridendron with a mixed sequence and a DNA crosslinker (B). Both systems have the ability to form a three-dimensional network by means of specific W-C base pairing.| File | Dimensione | Formato | |
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